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  • 1
    Publication Date: 2015-07-08
    Description: Protease-activated receptor-1 (PAR1) is a G-protein-coupled receptor (GPCR) for the coagulant protease thrombin. Similar to other GPCRs, PAR1 is promiscuous and couples to multiple heterotrimeric G-protein subtypes in the same cell and promotes diverse cellular responses. The molecular mechanism by which activation of a given GPCR with the same ligand...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
    Publication Date: 2016-01-29
    Description: There is growing evidence that chromosome territories (CT) have a probabilistic non-random arrangement within the cell nucleus of mammalian cells including radial positioning and preferred patterns of interchromosomal interactions that are cell-type specific. While it is generally assumed that the three-dimensional (3D) arrangement of genes within the CT is linked to genomic regulation, the degree of non-random organization of individual CT remains unclear. As a first step to elucidating the global 3D organization (topology) of individual CT, we performed multi-color fluorescence in situ hybridization using six probes extending across each chromosome in human WI38 lung fibroblasts. Six CT were selected ranging in size and gene density (1, 4, 12, 17, 18 and X). In-house computational geometric algorithms were applied to measure the 3D distances between every combination of probes and to elucidate data-mined structural patterns. Our findings demonstrate a high degree of non-random arrangement of individual CT that vary from chromosome to chromosome and display distinct changes during the cell cycle. Application of a classic, well-defined data mining and pattern recognition approach termed the ‘ k -means’ generated 3D models for the best fit arrangement of each chromosome. These predicted models correlated well with the detailed distance measurements and analysis. We propose that the unique 3D topology of each CT and characteristic changes during the cell cycle provide the structural framework for the global gene expression programs of the individual chromosomes.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 3
    Publication Date: 2019
    Description: Although Bangladesh has suffered from different types of floods which have caused enormous damage to properties and lives, managing floods still remains a challenging task. Flood management is a multisectoral activity due to its complexity, scale, and multidisciplinary nature. Sirajganj district can be regarded as one of the most vulnerable areas in Bangladesh and hence a study was carried out for Sirajganj district to provide guidelines to combat challenges to flood risk management. The flood frequency analyses at three river stations using water level data were carried out, the flood inundation map for different return periods and a flood depth versus damage curve are plotted to address the vulnerable areas and damages, and to help design flood mitigation structures. It can be inferred that damages will be proportional to return period since the risk is a function of hazard, vulnerability, and exposure. Both structural and non‐structural measures including rejuvenation of the Jamuna River and low‐cost flood resistant building approaches for flood affected char (island) people are suggested along with a few recommendations to mitigate floods in the study area. The government, Non governmental organization (NGO), funding agencies, and transboundary countries should come forward to mitigate flood hazards to improve the livelihood of the affected people.
    Electronic ISSN: 1753-318X
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Published by Wiley
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  • 4
    Publication Date: 2005-09-10
    Description: On 4 July 2005, many observatories around the world and in space observed the collision of Deep Impact with comet 9P/Tempel 1 or its aftermath. This was an unprecedented coordinated observational campaign. These data show that (i) there was new material after impact that was compositionally different from that seen before impact; (ii) the ratio of dust mass to gas mass in the ejecta was much larger than before impact; (iii) the new activity did not last more than a few days, and by 9 July the comet's behavior was indistinguishable from its pre-impact behavior; and (iv) there were interesting transient phenomena that may be correlated with cratering physics.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meech, K J -- Ageorges, N -- A'Hearn, M F -- Arpigny, C -- Ates, A -- Aycock, J -- Bagnulo, S -- Bailey, J -- Barber, R -- Barrera, L -- Barrena, R -- Bauer, J M -- Belton, M J S -- Bensch, F -- Bhattacharya, B -- Biver, N -- Blake, G -- Bockelee-Morvan, D -- Boehnhardt, H -- Bonev, B P -- Bonev, T -- Buie, M W -- Burton, M G -- Butner, H M -- Cabanac, R -- Campbell, R -- Campins, H -- Capria, M T -- Carroll, T -- Chaffee, F -- Charnley, S B -- Cleis, R -- Coates, A -- Cochran, A -- Colom, P -- Conrad, A -- Coulson, I M -- Crovisier, J -- deBuizer, J -- Dekany, R -- de Leon, J -- Dello Russo, N -- Delsanti, A -- DiSanti, M -- Drummond, J -- Dundon, L -- Etzel, P B -- Farnham, T L -- Feldman, P -- Fernandez, Y R -- Filipovic, M D -- Fisher, S -- Fitzsimmons, A -- Fong, D -- Fugate, R -- Fujiwara, H -- Fujiyoshi, T -- Furusho, R -- Fuse, T -- Gibb, E -- Groussin, O -- Gulkis, S -- Gurwell, M -- Hadamcik, E -- Hainaut, O -- Harker, D -- Harrington, D -- Harwit, M -- Hasegawa, S -- Hergenrother, C W -- Hirst, P -- Hodapp, K -- Honda, M -- Howell, E S -- Hutsemekers, D -- Iono, D -- Ip, W-H -- Jackson, W -- Jehin, E -- Jiang, Z J -- Jones, G H -- Jones, P A -- Kadono, T -- Kamath, U W -- Kaufl, H U -- Kasuga, T -- Kawakita, H -- Kelley, M S -- Kerber, F -- Kidger, M -- Kinoshita, D -- Knight, M -- Lara, L -- Larson, S M -- Lederer, S -- Lee, C-F -- Levasseur-Regourd, A C -- Li, J Y -- Li, Q-S -- Licandro, J -- Lin, Z-Y -- Lisse, C M -- LoCurto, G -- Lovell, A J -- Lowry, S C -- Lyke, J -- Lynch, D -- Ma, J -- Magee-Sauer, K -- Maheswar, G -- Manfroid, J -- Marco, O -- Martin, P -- Melnick, G -- Miller, S -- Miyata, T -- Moriarty-Schieven, G H -- Moskovitz, N -- Mueller, B E A -- Mumma, M J -- Muneer, S -- Neufeld, D A -- Ootsubo, T -- Osip, D -- Pandea, S K -- Pantin, E -- Paterno-Mahler, R -- Patten, B -- Penprase, B E -- Peck, A -- Petitas, G -- Pinilla-Alonso, N -- Pittichova, J -- Pompei, E -- Prabhu, T P -- Qi, C -- Rao, R -- Rauer, H -- Reitsema, H -- Rodgers, S D -- Rodriguez, P -- Ruane, R -- Ruch, G -- Rujopakarn, W -- Sahu, D K -- Sako, S -- Sakon, I -- Samarasinha, N -- Sarkissian, J M -- Saviane, I -- Schirmer, M -- Schultz, P -- Schulz, R -- Seitzer, P -- Sekiguchi, T -- Selman, F -- Serra-Ricart, M -- Sharp, R -- Snell, R L -- Snodgrass, C -- Stallard, T -- Stecklein, G -- Sterken, C -- Stuwe, J A -- Sugita, S -- Sumner, M -- Suntzeff, N -- Swaters, R -- Takakuwa, S -- Takato, N -- Thomas-Osip, J -- Thompson, E -- Tokunaga, A T -- Tozzi, G P -- Tran, H -- Troy, M -- Trujillo, C -- Van Cleve, J -- Vasundhara, R -- Vazquez, R -- Vilas, F -- Villanueva, G -- von Braun, K -- Vora, P -- Wainscoat, R J -- Walsh, K -- Watanabe, J -- Weaver, H A -- Weaver, W -- Weiler, M -- Weissman, P R -- Welsh, W F -- Wilner, D -- Wolk, S -- Womack, M -- Wooden, D -- Woodney, L M -- Woodward, C -- Wu, Z-Y -- Wu, J-H -- Yamashita, T -- Yang, B -- Yang, Y-B -- Yokogawa, S -- Zook, A C -- Zauderer, A -- Zhao, X -- Zhou, X -- Zucconi, J-M -- New York, N.Y. -- Science. 2005 Oct 14;310(5746):265-9. Epub 2005 Sep 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Astronomy, University of Hawaii at Manoa, 2680 Woodlawn Drive, Honolulu, HI 96822, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16150977" target="_blank"〉PubMed〈/a〉
    Keywords: Cosmic Dust ; Jupiter ; *Meteoroids ; Organic Chemicals ; Photometry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2016-03-17
    Description: We investigate optical reprocessing of X-rays in the low-mass X-ray binary (LMXB) pulsar 4U 1626–67 in its current spin-up phase using observations with Southern African Large Telescope (SALT), near-simultaneous observations with Swift -X-ray Telescope and non-simultaneous RXTE -Proportional Counter Array (PCA) observations and present the results of timing analysis. Using SALT observations carried out on 2014 March 5 and 6, we detect some interesting reprocessing signatures. We detect a weak optical quasiperiodic oscillation (QPO) in the power density spectrum on March 5 at 48 mHz with a fractional rms of 3.3 per cent in spite of the fact that source shows no corresponding X-ray QPO in the spin-up phase. In the light curve obtained on March 5, we detect a coherent pulsation at the spin period of ~7.677 s. A previously known, slightly down-shifted side-band is also detected at 129.92 mHz. The frequency spacing between main pulse and this side-band is different from earlier observations, though the statistical significance of the difference is limited. The light curve of March 6 displays short time-scale variability in the form of flares on time-scales of a few minutes. Folded pulse profiles resulting from data of this night show an interesting trend of pulse peak drifting. This drift could be due to (i) rapid changes in the reprocessing agent, like orbital motion of an accretion disc warp around the neutron star, or (ii) intrinsic pulse phase changes in X-rays. We also examine some X-ray light curves obtained with RXTE -PCA during 2008–2010 for pulse shape changes in short time-scales during X-ray flares.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters A 133 (1988), S. 105-108 
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 214 (1967), S. 708-709 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Diphenyl sulphone 4 : 4'-di-isothiocyanate was supplied by Dr. R. N. Iyer, of the Medicinal Chemistry Division of this Institute. The compound is insoluble in water, acid or alkali. SCN--NCS The strain of Hymenolepis nana used in these investigations was obtained from the Wellcome Laboratories of ...
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Specimens of about 1-5 ml. of semen from either Hereford or Friesian bulls were provided by the Cambridge Cattle Breeding Centre. After 24 h for treatment at Babraham to separate the fast and slowly sedimenting spermatozoa, samples from the top and bottom of the columns were given code numbers and ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 207 (1965), S. 1259-1260 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] REMARKABLY little nas been done to find an ideal cesticide, and the extract of male fern (Dryopteris filix-mas), which has been in use from medieval times, is still the drug of choice. Yet this and other drugs like quinacrine, dichlorophen, hexylresorcinol, arecoline, etc., are rather toxic and ...
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 40 (1992), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: The induced polarization response for a 2D horizontal cylinder embedded in a half-space is calculated for a uniform electric source. Response curves, in the form of apparent charge-ability taking into account the effect of the air-earth interface, exhibit a sharp decrease in amplitude with an increase in depth of burial of the target. The resistivity contrast between the cylinder and the host plays a dominant role in determining the IP response, i.e. the amplitude decreases considerably with the increase in resistivity contrast. The decrease is due to the defocusing effect caused by the resistive cylinder. The current lines tend to deviate away from the cylindrical target. In the case of a highly conducting cylinder, apparent defocusing takes place as current lines are confined to the surface of the conducting cylinder. An increase in chargeability contrast is reflected as a steady rise in the response. The peak response at the centre is reduced by about half the magnitude when the air–earth interface is not considered. The variation of response along the profile, though noticeable, is not as high as that obtained at the centre.
    Type of Medium: Electronic Resource
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