Publication Date:
1992-10-30
Description:
Selective events during T cell repertoire development in the thymus include both the positive selection of cells whose receptors recognize self-major histocompatibility complex (MHC) molecules and negative selection (tolerance) of cells whose interaction with self-MHC is of high affinity. The affinity of T cell interactions with class I MHC molecules includes contributions by both the T cell receptor and the CD8 coreceptor. Therefore, by decreasing the affinity of the interaction with CD8, T cells whose receptors have relatively high affinities for self-MHC may survive negative selection. Such T cells were generated and those T cells reactive with self-MHC plus antigen also displayed low affinity for self.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sherman, L A -- Hesse, S V -- Irwin, M J -- La Face, D -- Peterson, P -- CA 25803/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1992 Oct 30;258(5083):815-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1439792" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD8/*immunology
;
Antigens, Viral/immunology
;
H-2 Antigens/genetics/immunology
;
HLA-A2 Antigen/genetics/immunology
;
Histocompatibility Antigens Class I/*immunology
;
Humans
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*Immune Tolerance
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Influenza A virus/immunology
;
Mice
;
Mice, Transgenic
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Receptors, Antigen, T-Cell/*immunology
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T-Lymphocytes, Cytotoxic/immunology
;
Thymus Gland/growth & development/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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