Publication Date:
1978-07-21
Description:
Nineteen normal male subjects received 1.0 milligram of physostigmine or 1.0 milligram of saline by a slow intravenous infusion on two nonconsecutive days. Physostigmine significantly enhanced storage of information into long-term memory. Retrieval of information from long-term memory was also improved. Short-term memory processes were not significantly altered by physostigmine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, K L -- Mohs, R C -- Tinklenberg, J R -- Pfefferbaum, A -- Hollister, L E -- Kopell, B S -- New York, N.Y. -- Science. 1978 Jul 21;201(4352):272-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351807" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylcholine/physiology
;
Adolescent
;
Adult
;
Alzheimer Disease/drug therapy
;
Clinical Trials as Topic
;
Humans
;
Male
;
Memory/*drug effects/physiology
;
Memory, Short-Term/drug effects
;
Physostigmine/*pharmacology/therapeutic use
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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