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  • 1
    Online Resource
    Online Resource
    Neuroimmune Interactions in Pain : Mechanisms and Therapeutics (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Pain medicine. ; Neurology . ; Anesthesiology. ; Neuroscience. ; Pain Medicine. ; Neurology. ; Anesthesiology.
    Description / Table of Contents: Introduction to Acute, Chronic, and Episodic Pain -- Inflammation and Pain -- Animal Models of Pain and Anti-inflammatory Treatments -- Inflammatory Mediators, Nociceptors, and Their Interactions in Pain -- Immune and Glial Cells in Pain and Their Interactions with Nociceptive Neurons -- Sex Differences in Neuroimmune Interactions and Pain -- Neuroimmune Interactions in Itch -- Toll-like Receptors in Pain and Itch -- Immunotherapy and Pain -- Cell Therapy and Regenerative Pain Medicine - Preclinical Studies -- Cell-based Therapies in Pain Management -- Platelet-Rich Plasma and Autologous Conditioned Serum: Non-Cellular Biologic Therapies for Neuroimmune Modulation and the Treatment of Arthritis Pain -- Exercise and Diet in the Control of Inflammation and Pain -- Mechanism-Based Pain Therapies -- Neuromodulation in Pain Management -- What Patients Need to Know about Pain Therapy?.
    Abstract: As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.
    Type of Medium: Online Resource
    Pages: X, 364 p. 45 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031292316
    URL: https://doi.org/10.1007/978-3-031-29231-6
    DOI: 10.1007/978-3-031-29231-6
    DDC: 612.8
    Language: English
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  • 2
    Online Resource
    Online Resource
    Defining Physiology: Principles, Themes, Concepts. Volume 2 : Neurophysiology and Gastrointestinal Systems (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Human physiology. ; Neurology . ; Anatomy. ; Neurosciences. ; Internal medicine. ; Human Physiology. ; Neurology. ; Anatomy. ; Neuroscience. ; Internal Medicine.
    Description / Table of Contents: Salivary gland: Savilon -- Oesophageal sphincters: Upper oesophageal sphincter and lower oesophageal sphincter -- Stomach as an Acid Producer -- Homeostasis of gastric acid secretion: neurocrine, paracrine and endocrine system, proton pump inhibitors. Alkaline tide -- Gastric mucosal barrier, Helicobacter pylori -- Gastric motility: (Migrating Motor Complex, Receptive Relaxation, Accommodation, Retropulsion) -- Gastric Emptying -- Gastrointestinal Rhythmic Contractions Electrical Basis: Slow wave potential -- Migratory Motor Complex (or migrating myoelectric complex), MMC, Motilin -- Motility: Peristalsis, Segmentation, Haustration and Mass movement -- Motility: Peristalsis, Segmentation, Haustration and Mass movement -- Recycling of bile salts: Enterohepatic Circulation (EHC) -- Intestinal Fluid Handling: Absorption -- Intestinal Fluid Handling: Secretion -- Pancreatic Exocrine function: Pancreatic acinar cell in pancreatic secretion, cholecystokinin (CCK), Auto- digestion -- Pancreatic Exocrine function: Pancreatic ductal cell, CFTR chloride channel. Secretin -- Carbohydrate Digestion: Small intestine as the site of digestion and absorption for dietary carbohydrate -- Fat digestion: Bile salt, emulsification, micelles, lipases, chylomicrons -- Protein Digestion -- Protein Absorption -- Defecation Reflex: Parasympathetic defecation reflex, intrinsic myenteric defection reflex -- Resting Membrane Potential (RMP) -- Equilibrium Potential -- Membrane conductance -- Action Potential -- Neuronal excitability -- Neuronal refractory period -- Initiation zone -- Saltatory conduction -- Firing rate -- Post-synaptic potentials -- Synaptic delay -- Summation -- Neurotransmitter -- Presynaptic inhibition -- Adequate stimulus -- Stimulus transduction -- Stimulus coding -- Adaptation -- Sensory discrimination (acuity) -- Motor neurons -- Neuromuscular junction -- Proprioception -- Spinal reflex -- Alpha-gamma coactivation.
    Abstract: This second volume of Defining Physiology: Principles, Themes, Concepts. continues on the same format as the first. In this new release, a selection of 44 essential topics in each major organ system is defined, then major themes, concept and principles surrounding these words in their physiologic scenarios are elaborated. For each keyword, a question is posed at the end of the text to test for a better understanding of the associated physiology of nervous and gastrointestinal systems. This book presents an easy reference guide for those just starting out in the area of physiology and for those who are interested in clear and succinct definitions of key terms.
    Type of Medium: Online Resource
    Pages: XII, 112 p. 42 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030622855
    URL: https://doi.org/10.1007/978-3-030-62285-5
    DOI: 10.1007/978-3-030-62285-5
    DDC: 612
    Language: English
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  • 3
    Online Resource
    Online Resource
    Sphingolipid Metabolism and Metabolic Disease (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Diseases. ; Internal medicine. ; Biomedical Research. ; Diseases. ; Internal Medicine.
    Description / Table of Contents: Chapter 1: Sphingolipids and Cholesterol -- Chapter 2: Sphingolipids in adipose: kin or foe? -- Chapter 3: De novo sphingolipid biosynthesis in atherosclerosis -- Chapter 4: Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases -- Chapter 5: Molecular mechanisms of sphingolipid transport on plasma lipoproteins -- Chapter 6: Sphingosine 1-phosphate metabolism and signaling -- Chapter 7: Sphingomyelin synthase family and phospholipase Cs -- Chapter 8: Sphingolipid metabolism and signaling in endothelial cell functions -- Chapter 9: Cholesterol metabolism in chronic kidney disease: physiology, pathologic mechanisms, and treatment -- Chapter 10: Sphingolipids and asthma -- Chaper 11: Manifold Roles of Ceramide Metabolism in Nonalcoholic Fatty Liver Disease and Liver Cancer -- Chapter 12: Drug development in the field of sphinogolipid metabolism -- Chapter 13: Rare diseases in glycosphingolipid metabolism.
    Abstract: This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.
    Type of Medium: Online Resource
    Pages: VIII, 213 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811903946
    Series Statement: Advances in Experimental Medicine and Biology, 1372
    URL: https://doi.org/10.1007/978-981-19-0394-6
    DOI: 10.1007/978-981-19-0394-6
    DDC: 610.72
    Language: English
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  • 4
    Online Resource
    Online Resource
    Molecular Mechanisms in Spermatogenesis (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Reproductive health. ; Cytology. ; Biomedical Research. ; Reproductive Medicine. ; Cell Biology.
    Description / Table of Contents: Ch 1: The seminiferous epithelial cycle of spermatogenesis: Role of non-receptor protein kinases -- Ch 2: Sertoli cells: immunology and spermatogenesis -- Ch 3: Innate immunity and spermatogenesis -- Ch 4: Cell apoptosis and spermatogenesis -- Ch 5: Transcriptional regulation of spermatogenesis -- Ch 6: Sertoli cell cytoskeleton and spermatogenesis -- Ch 7: Leydig cell and spermatogenesis -- Ch 8: Cross-talk of cell junctions to support spermatogenesis -- Ch 9: Coordination of F-actin- and MT-based cytoskeletons to support spermatogenesis -- Ch 10: Regulation of the blood-testis barrier by basement membrane laminin-α2 chain -- Ch 11: Regulation of spermatogenesis by collagens -- Ch 12: Androgen regulation of spermatogenesis -- Ch 13: Use of molecular modeling to study spermatogenesis -- Ch 14: Acrosome biogenesis during spermatogenesis -- Ch 15: Stem cells and spermatogenesis -- Ch 16: Advances in our understanding of spermatogenesis in humans -- Ch 17: Leydig cell function in aging men -- Ch 18: Regulation of human spermatogenesis.
    Abstract: This new edition provides an update on the molecular mechanisms that regulate spermatogenesis. In addition to the rodent as a study model, chapters also include research on studies in humans. It includes the latest approaches of studying spermatogenesis, such as the use of bioinformatics, molecular modeling and others which are not commonly found in published materials. It also reviews the latest developments in the field, such as studies on the role of regulatory RNAs on spermatogenesis. Due to the declining fertility rate among men, a brand new chapter highlights the impact of environmental toxicants on spermatogenesis.
    Type of Medium: Online Resource
    Pages: X, 319 p. 44 illus., 40 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030777791
    Series Statement: Advances in Experimental Medicine and Biology, 1381
    URL: https://doi.org/10.1007/978-3-030-77779-1
    DOI: 10.1007/978-3-030-77779-1
    DDC: 610.72
    Language: English
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  • 5
    Online Resource
    Online Resource
    Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Human physiology. ; Lipids. ; Cardiovascular system. ; Physiology. ; Human Physiology. ; Lipidology. ; Cardiovascular Physiology.
    Description / Table of Contents: Chapter 1: Impact of Phospholipid Transfer Protein in Lipid Metabolism and Cardiovascular Diseases -- Chapter 2: Cholesteryl Ester Transfer Protein and Lipid Metabolism and Cardiovascular Diseases -- Chapter 3: Lipopolysaccharide Binding Protein and Bactericidal/Permeability-increasing Protein in Lipid Metabolism and Cardiovascular Diseases -- Chapter 4: Microsomal Triglyceride Transfer Protein: From Lipid Metabolism to Metabolic Diseases -- Chapter 5: Circadian-Clock Regulation on Lipid Metabolism and Metabolic Diseases -- Chapter 6: ABC Transporters, Cholesterol Efflux and Implications for Cardiovascular Diseases -- Chapter 7: Apolipoprotein M: research progress and clinical perspective -- Chapter 8: Recent Advances in the Critical Role of the Sterol Efflux Transporters ABCG5/G8 in Health and Disease -- Chapter 9: Proprotein Convertase Subtilisin/Kexin-type 9 and Lipid Metabolism -- Chapter 10: LDL and HDL Oxidative Modification and Atherosclerosis -- Chapter 11: Rare Diseases Related with Lipoprotein Metabolism -- Chapter 12: Preβ1 High Density Lipoprotein in Cardiovascular Diseases -- Chapter 13: CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis -- Chapter 14: Mfsd2a, a physiologically important lysolipid transporter in brain and eye.
    Abstract: This book provides an up-to-date review of the fundamentals of lipid metabolism and its role in cardiovascular diseases. Focusing on lipid transfer proteins in the circulation and cells, the role of important lipid transporters, the effect of recently discovered lipid binding proteins, and the link between lipid metabolism disorders and cardiovascular diseases, it covers phospholipid transfer protein, cholesteryl ester transfer protein, lipopolysaccharide binding protein, microsomal triglyceride transfer protein, ABC binding cassette members, and more. The book offers graduate students and researchers a coherent overview of lipid transfer and transport, as well as the limitations of current research in the field, and promotes further studies on cardiovascular diseases, as well as pharmaceutical research on drug discovery based on lipid transfer, transport, and binding.
    Type of Medium: Online Resource
    Pages: VIII, 234 p. 38 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811560828
    Series Statement: Advances in Experimental Medicine and Biology, 1276
    URL: https://doi.org/10.1007/978-981-15-6082-8
    DOI: 10.1007/978-981-15-6082-8
    DDC: 612
    Language: English
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  • 6
    Online Resource
    Online Resource
    Reconstruction of Urban Forests : Post World War II and the Bosnian War (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Urban ecology (Biology). ; Cities and towns History. ; Human ecology History. ; Human geography. ; Geography. ; Urban Ecology. ; Urban History. ; Environmental History. ; Human Geography. ; Regional Geography.
    Description / Table of Contents: 1. Introduction -- 2. Aerial bombing of cities during World War II -- 3. London -- 4. Coventry -- 5. Hamburg -- 6. Dresden -- 7. St. Petersburg -- 8. Stalingrad -- 9. Tokyo -- 10. Hiroshima -- 11. Conclusions.
    Abstract: This book will address the destruction of urban forest in nine cities by bombing during World War II and the Bosnian War and their reconstruction in the post-war years. After reviewing the general objectives and results of aerial bombing, the book explores the effects of bombing and the reconstruction of urban forest in London, Coventry, Hamburg, Dresden, St. Petersburg, Stalingrad, Tokyo, Hiroshima, and Sarajevo. Sarajevo stands out among these cities because the destruction of its urban forest was the result of citizens cutting down trees for firewood during the siege of the city. Most of the cities studied developed plans for reconstruction either during or after the war. These plans often addressed the planning and re-establishment of the urban forest that had been destroyed. Urban planners often planned for infrastructure improvements such as new boulevards and parks where trees would be planted. After the war many of these plans were abandoned or significantly modified. Cost, resistance by property owners, control of reconstruction by authorities outside of the cities, and the lack of planting stock were factors contributing to the failure of many of the plans. Exceptions occurred in Hiroshima and Coventry where the destroyed cities became symbols of national reconstruction and every effort was made to redesign the destroyed portions of these cities as memorials to those who lost their lives and to demonstrate the rebirth of the cities. In several of the cities studied individual citizens undertook on their own the replanting of street and park trees. Their ingenuity, hard work, and dedication to trees in their cities was remarkable. A common factor limiting efforts to replant street and park trees was the lack of nursery stock. During and immediately after the wars nearly all nurseries that had supplied trees for city planting had been converted to vegetable gardens to produce food for the urban populations. The slow return to the production of trees for urban planting was a common factor in the time required in many cities to restore their street and park trees. There are lessons to be learned by urban planner, urban forester, and landscape architects from this book that will be useful in the future destruction of urban forest either by natural or man-made causes.
    Type of Medium: Online Resource
    Pages: X, 106 p. 33 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030649388
    URL: https://doi.org/10.1007/978-3-030-64938-8
    DOI: 10.1007/978-3-030-64938-8
    DDC: 577.56
    Language: English
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  • 7
    Online Resource
    Online Resource
    Green Technologies and Infrastructure to Enhance Urban Ecosystem Services : Proceedings of the Smart and Sustainable Cities Conference 2018 (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Human geography. ; Urban ecology (Biology). ; Sustainability. ; Soil science. ; Physical geography. ; Human Geography. ; Urban Ecology. ; Sustainability. ; Soil Science. ; Physical Geography.
    Abstract: These proceedings of the Smart and Sustainable Cities Conference (SSC) in Moscow from May 23 to 26, 2018 addresses important questions regarding the global trend of urbanization. What are the environmental consequences of megacities’ expansion? What smart solutions can make life in cities safe, comfortable and environmentally friendly? It is projected that 70% of the global population will live in cities by 2050, and as such the book describes how this rapid urbanization will alter the face of the world. Focusing on solutions for the environmental problems of modern megapolises, it discusses advanced approaches and smart technologies to monitor, model and assess the environmental consequences and risks. The contributors present examples of successful sustainable urban development, including management and design of green infrastructure, waste management, run-off purification and remediation of urban soils. The SSC conference and its proceedings offer a valuable contribution to sustainable urban development, and are of interest to the scientific and research community, municipal services, environmental protection agencies, landscape architects, civil engineers, policy makers and other stakeholders in urban management and greenery.
    Type of Medium: Online Resource
    Pages: XIII, 280 p. 117 illus., 97 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030160913
    Series Statement: Springer Geography,
    URL: https://doi.org/10.1007/978-3-030-16091-3
    DOI: 10.1007/978-3-030-16091-3
    DDC: 304.2
    Language: English
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  • 8
    Online Resource
    Online Resource
    Paths to Clean Water Under Rapid Changing Environment in China (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pollution. ; Water. ; Hydrology. ; Environmental monitoring. ; Freshwater ecology. ; Marine ecology. ; Pollution. ; Water. ; Environmental Monitoring. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Current situation of water pollution in China -- Challenges and opportunities to treat water pollution -- Facing water pollution under rapid changing environment: China’s experiences -- Conclusion.
    Abstract: This book mainly provides the current status of water pollution faced by China under rapid changing environment and the actions that have been taken for prevention and treatment of water pollution. It points out that the water pollution situation is severe. Facing water pollution, China’s experiences include several aspects on source control and pollution interception, internal nutrient removal of sediment, ecological restoration, and water transfer policy. There exists both the opportunity and challenge for the prevention and control of water pollution in China. The book contains numerous charts and diagrams which further illustrating China’s paths to clean water.
    Type of Medium: Online Resource
    Pages: VIII, 96 p. 29 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811900914
    Series Statement: SpringerBriefs in Water Science and Technology,
    URL: https://doi.org/10.1007/978-981-19-0091-4
    DOI: 10.1007/978-981-19-0091-4
    DDC: 363.73
    Language: English
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  • 9
    Online Resource
    Online Resource
    Advanced Tunneling Techniques and Information Modeling of Underground Infrastructure : Proceedings of the 6th GeoChina International Conference on Civil & Transportation Infrastructures: From Engineering to Smart & Green Life Cycle Solutions -- Nanchang, China, 2021 (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Engineering geology. ; Geoengineering.
    Description / Table of Contents: Chapter 1. Inception of Debris Avalanches: a Material Point Method Modelling -- Chapter 2. Research on the Calculation of Segment Floating Considering the Action Degree of Soil Arching Effect -- Chapter 3. Cause Analysis and Treatment Measures for Invert Heaving Disease of Railway Tunnel in Slightly Inclined Layered Rock Mass -- Chapter 4. A Semi-analytical Model for Compaction-grouted Soil Nails -- Chapter 5. Buckling Analysis of Mono-bucket Foundation with Compartments during Suction Installation -- Chapter 6. PCPT and SPT as Complementary Tests for the Formulation of Geotechnical Design Profiles -- Chapter 7. Research on the Rapid Detection Technology of Tunnel Lining Cracks and Accuracy Calibration based on Infrared Image -- Chapter 8. Research on the Construction of 3D Laser Scanning Tunnel Point Cloud based on B-spline Interpolation.
    Abstract: This volume contains a compilation of studies regarding novel technology of underground space development, behavior analysis and modelling of soils and underground infrastructure from the 6th GeoChina International Conference held in Nanchang, China from July 19 to 21, 2021. The scope of the studies covers both methodological and pragmatic solutions to critical issues, including soil arching and invert heaving, penetration resistance of mono-bucket foundations in silty soil, inception of debris avalanches, and novel infrastructure survey methods based on point cloud and image analysis. It is anticipated that this updated knowledge will lead to more resilient design, expedited inspection, timely maintenance and rehabilitation of underground infrastructure, and will be beneficial to both researchers and practitioners in the field.
    Type of Medium: Online Resource
    Pages: X, 119 p. 78 illus., 53 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030796723
    Series Statement: Sustainable Civil Infrastructures,
    URL: https://doi.org/10.1007/978-3-030-79672-3
    DOI: 10.1007/978-3-030-79672-3
    DDC: 624.15
    Language: English
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  • 10
    Online Resource
    Online Resource
    Mechanics of Bio-Sediment Transport (2020)
    Berlin, Heidelberg :Springer Berlin Heidelberg :
    Details
    Keywords: Environmental engineering. ; Biotechnology. ; Bioremediation. ; Environment. ; Water. ; Hydrology. ; Environmental Engineering/Biotechnology. ; Environmental Sciences. ; Water.
    Description / Table of Contents: Surface Micro-morphology and Adsorption Properties of Sediment -- Basic Characteristics of Bio-sediment -- Biofilm Growth and the Impacts on Hydrodynamics -- Bedload Transport of Bio-sediment -- Suspended Load Transport of Bio-sediment -- Numerical Simulation of Bio-sediment Transport.
    Abstract: The main focus of this book is the transport mechanics of sediment particles coated with microbial biofilm, which is called bio-sediment. The book also addresses the question of how to measure and simulate the considerable variation in the properties of natural sediment associated with microbial biofilm, ranging from the micro-scale surface morphology to the macro-scale sediment transport. Nowadays most studies to elucidate the mechanisms of sediment transport have concentrated on physical-chemical sediment properties, little work explicitly coupled sediment dynamics and the environmental effects under the influence of micro-ecosystem, thus leaving a serious gap in water and sediment sciences as well as water ecological research. With respect to physical-chemical sediment properties, this book has been undertaken to evaluate and quantify the effect of biological factors - biofilm on sediment transport mechanics. The chapters cover topics including development of bio-sediment and its properties; model of biofilm growth on sediment substratum; bedform and flow resistance of bio-sediment bed; incipient velocity and settling velocity of bio-sediment; bedload and suspended load transport for bio-sediment; numerical simulation of bio-sediment transport. Besides, the measurement technology, analysis method and expression approach introduced in this book combine the characteristics of hydraulic, environmental and microbial research, having more immediate innovation. This book will be of interest to researchers, managers, practitioners, policy and decision makers, international institutions, governmental and non-governmental organizations, educators, as well as graduate and undergraduate students in the field of hydraulics and river dynamics. It will help to understand the relevance of sediment transport and biofilm growth under the role of aqueous micro-ecosystem, to introduce better tools for the simulation and prediction of bio-sediment transport, and to provide a scientific basis and application foundation for the research of interaction between sediment particles and ecological and environmental factors.
    Type of Medium: Online Resource
    Pages: XXVIII, 388 p. 220 illus., 104 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783662611586
    URL: https://doi.org/10.1007/978-3-662-61158-6
    DOI: 10.1007/978-3-662-61158-6
    DDC: 628
    Language: English
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