Publication Date:
2017-05-10
Description:
Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice Nature Communications, Published online: 9 May 2017; doi:10.1038/ncomms15142 Mutation of the human gene PHF8 , encoding a histone demethylase, is linked to cognitive defects but its role in development is unclear. Here, the authors show that Phf8 deletion in mice causes no overt developmental defects but confers resilience to depression, likely through increased serotonin signalling.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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