ALBERT

Description: Sulfur dioxide ( SO 2 ) in the atmosphere has been demonstrated to have many adverse impacts on the environment and human health. In this study, deposition of SO 2 ranging from 9.0 to 127.8 mg kg −1 with an average of 35.7 mg S kg −1 was found to substantially stimulate NO and N 2 O emissions from soils in the humid subtropical areas of Hainan, Fujian, Jiangxi, and Yunnan provinces of China under field conditions. Laboratory tests indicated that the stimulations were mediated biologically as the effects were not observed in sterilized soils. Acidification of soil resulting from SO 2 deposition was not responsible for the stimulated NO and N 2 O emissions alone as the stimulation did not occur by acidifying soil with HNO 3 treatment. By using the 15 N tracing method, we found that the N 2 O emissions stimulated by SO 2 deposition were from either denitrification, heterotrophic nitrification or both, but not from autotrophic nitrification. Therefore, atmospheric SO 2 deposition would most likely stimulate NO and N 2 O emissions in acidic soils in which heterotrophic nitrification dominates NO and N 2 O production and waterlogged soils in which denitrification dominates NO and N 2 O production.

Description: Understanding ecological stoichiometric characteristics of soil nutrient elements is crucial to guide ecological restoration and agricultural cultivation in karst rocky desertification region, but the information about the effect of the geological background on ecological stoichiometric ratios remains unknown. Soils from different landforms, including a basin, slope, and plateau, were sampled to investigate the spatial variance of the ecological stoichiometric characteristics of soil carbon (C), nitrogen (N), and phosphorus (P) under different rocky desertification grades (LRD: light rocky desertification; MRD: moderate rocky desertification; and SRD: severe rocky desertification) in a karst graben basin of Southwest China. Soil C:N ratio was not significantly influenced by rocky desertification grade, which was at a relatively stable level in the same landform, but soil C:P and N:P ratios increased with increasing rocky desertification grade. This change was consistent with increased soil organic carbon (SOC) and total nitrogen (TN) concentrations in the same geomorphic location along with the intensification of rocky desertification, but soil P concentration remained at a relatively stable level, indicating that P may be the limiting macronutrient for plant growth during vegetation restoration in a karst graben area. The soil C:N ratio of slope land was larger than that of the basin and plateau, while the soil C:P ratio and N:P ratio of the slope and plateau were significantly larger than that of the basin. The correlations between pH and C, N, and P stoichiometry decreased significantly when Ca was used as a control variable. In sharp contrast, the correlations between Ca and C, N, and P stoichiometry were highly significant no matter whether pH was used as a control variable, suggesting the important role of Ca in soil C, N, and P stoichiometry in karst graben basins.

Description: Sulfur dioxide (SO 2 ) in the atmosphere has been demonstrated to have many adverse impacts on the environment and human health. In this study, deposition of SO 2 ranging from 9.0 to 127.8 mg kg −1 with an average of 35.7 mg S kg −1 was found to substantially stimulate NO and N 2 O emissions from soils in the humid subtropical areas of Hainan, Fujian, Jiangxi and Yunnan provinces of China under field conditions. Laboratory tests indicated that the stimulations were mediated biologically as the effects were not observed in sterilized soils. Acidification of soil resulting from SO 2 deposition was not responsible for the stimulated NO and N 2 O emissions alone as the stimulation did not occur by acidifying soil with HNO 3 treatment. By using the 15 N tracing method, we found that the N 2 O emissions stimulated by SO 2 deposition were from either denitrification, heterotrophic nitrification or both, but not from autotrophic nitrification. Therefore, atmospheric SO 2 deposition would most likely stimulate NO and N 2 O emissions in acidic soils in which heterotrophic nitrification dominates NO and N 2 O production and waterlogged soils in which denitrification dominates NO and N 2 O production.

Description: Waste-rock material used in underground backfill mining has a granular texture and acquires non-linear deformation characteristics when compressed. The deformation modulus of waste-rock measured by a laboratory compression test is significantly different from the true deformation modulus in the field, due to the complete confining effect of the loading steel cylinder. In this study, we performed a series of laboratory-based compression tests on waste-rock samples. The results showed that lab-acquired deformation modulus variations of waste rock could be divided into three stages: slow increase, accelerated increase, and rapid increase. We also measured the true deformation modulus of backfill waste rock by conducting a field test in gob areas of the Tangshan coal mine, China. The hardening process of backfill waste rock during the field test was analyzed, and could be divided into four stages: roof contact, rapid compression, slow compression, and long-term stable. With the increase of axial strain, the lab- and field-measured deformation moduli of waste rock both increased exponentially. A correction parameter was proposed to investigate the relationship between the field-generated true deformation modulus and the lab-tested deformation modulus. The correction parameter k positively correlated with the axial strain, in the form of an exponential function. The magnitude of k was between 0.5616 and 0.6531.

Description: Research on energy accumulation and releasing in the rock plays a key role on revealing its failure mechanism. This paper establishes a microscopic structure model of granite using Otsu digital image processing (DIP) technology and particle flow code software (PFC2D). A series of numerical compression tests under different confining pressures were conducted to investigate the macro and micro characteristics of energy evolution in granite. The results showed that the energy evolution of granite is divided into three stages: stable accumulation, slow dissipation, and rapid release. With increasing confining pressure, the strain energy accumulation ratio decreased exponentially and the peak value of strain energy increased linearly. It was found that the energy accumulation speed in the pre-peak stage increased as a linear function, while the energy release speed in the post-peak stage decreased as an exponential function. In addition, the feldspar is the main microstructure which played a major part in accumulating energy in granite. However, the unit mineral energy of mica particles was bigger than that of feldspar and quartz. When subjected to increasing confining pressure, the feldspar’s total energy growth rate was fastest. Meanwhile, the mica’s unit energy growth rate was fastest.

Description: Background In this work, we aimed to demonstrate how to utilize the lab test results and other clinical information to support precision medicine research and clinical decisions on complex diseases, with the support of electronic medical record facilities. We defined “clinotypes” as clinical information that could be observed and measured objectively using biomedical instruments. From well-known ‘omic’ problem definitions, we defined problems using clinotype information, including stratifying patients—identifying interested sub cohorts for future studies, mining significant associations between clinotypes and specific phenotypes-diseases, and discovering potential linkages between clinotype and genomic information. We solved these problems by integrating public omic databases and applying advanced machine learning and visual analytic techniques on two-year health exam records from a large population of healthy southern Chinese individuals (size n = 91,354). When developing the solution, we carefully addressed the missing information, imbalance and non-uniformed data annotation issues. Results We organized the techniques and solutions to address the problems and issues above into CPA framework (Clinotype Prediction and Association-finding). At the data preprocessing step, we handled the missing value issue with predicted accuracy of 0.760. We curated 12,635 clinotype-gene associations. We found 147 Associations between 147 chronic diseases-phenotype and clinotypes, which improved the disease predictive performance to AUC (average) of 0.967. We mined 182 significant clinotype-clinotype associations among 69 clinotypes. Conclusions Our results showed strong potential connectivity between the omics information and the clinical lab test information. The results further emphasized the needs to utilize and integrate the clinical information, especially the lab test results, in future PheWas and omic studies. Furthermore, it showed that the clinotype information could initiate an alternative research direction and serve as an independent field of data to support the well-known ‘phenome’ and ‘genome’ researches.