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  • 1
    Publication Date: 2024-01-08
    Description: In this paper, we provide a characterisation of the ionosphere from April 2018 to September 2022 for 48 investigated months. We used the data of the China Seismo Electromagnetic Satellite (CSES-01), which is a sun-synchronous satellite with five days of revisit time and fixed local time of about 2 a.m. and 2 p.m. The unique orbit of CSES-01 permitted us to produce a monthly background of the ionosphere for night- and daytime with median values acquired during geomagnetic quiet time in equatorial and mid-latitude regions (i.e., between 50° S and 50° N of geographical latitude). We compared the obtained CSES-01 monthly median values with the solar activity in terms of sunspot numbers, and we found a high correlation of 0.89 for nighttime and 0.85 for daytime between the mean sunspot number and the maximum of the characterised CSES-01 Ne map values. In addition, we extracted all the anomalous positive increases in CSES-01 electron density and compared them with the Worldwide M5.5+ shallow earthquakes. We tested two different definitions of anomaly based on median and interquartile range or (mild) outliers. We tried two relationships between anomalies inside Dobrovolsky’s area before the earthquake and the magnitude of the same seismic events: one which considers distance in space and time and a second which only uses the anticipation time of the anomaly before the earthquake. Using both anomaly definitions, we searched the best coefficients for these two laws for mid-latitude and equational regions. We found that the best coefficients are independent of the anomaly definition, but better accuracy (greater than 80%) is obtained for the outlier definition. Finally, using receiving operating characteristic (ROC) curves, we show that CSES-01 increases seem statistically correlated to the incoming seismic activity.
    Description: Published
    Description: 1527
    Description: OST4 Descrizione in tempo reale del terremoto, del maremoto, loro predicibilità e impatto
    Description: OSA3: Climatologia e meteorologia spaziale
    Description: JCR Journal
    Keywords: CSES ; electron density ; earthquake ; ionosphere ; satellite background ; 01.02. Ionosphere ; 04.06. Seismology ; 05.07. Space and Planetary sciences
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 2
    Publication Date: 2023-02-01
    Description: Nowadays, the possibility that medium-large earthquakes could produce some electromagnetic ionospheric disturbances during their preparatory phase is controversial in the scientific community. Some previous works using satellite data from DEMETER, Swarm and, recently, CSES provided several pieces of evidence supporting the existence of such precursory phenomena in terms of single case studies and statical analyses. In this work, we applied a Worldwide Statistical Correlation approach to M5.5+ shallow earthquakes using the first 8 years of Swarm (i.e., from November 2013 to November 2021) magnetic field and electron density signals in order to improve the significance of previous statistical studies and provide some new results on how earthquake features could influence ionospheric electromagnetic disturbances. We implemented new methodologies based on the hypothesis that the anticipation time of anomalies of larger earthquakes is usually longer than that of anomalies of smaller magnitude. We also considered the signal’s frequency to introduce a new identification criterion for the anomalies. We find that taking into account the frequency can improve the statistical significance (up to 25% for magnetic data and up to 100% for electron density). Furthermore, we noted that the frequency of the Swarm magnetic field signal of possible precursor anomalies seems to slightly increase as the earthquake is approaching. Finally, we checked a possible relationship between the frequency of the detected anomalies and earthquake features. The earthquake focal mechanism seems to have a low or null influence on the frequency of the detected anomalies, while the epicenter location appears to play an important role. In fact, land earthquakes are more likely to be preceded by slower (lower frequency) magnetic field signals, whereas sea seismic events show a higher probability of being preceded by faster (higher frequency) magnetic field signals.
    Description: Published
    Description: 2649
    Description: 7T. Variazioni delle caratteristiche crostali e "precursori"
    Description: 1A. Geomagnetismo e Paleomagnetismo
    Description: 5IT. Osservazioni satellitari
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
    Publication Date: 2024-04-30
    Description: Earthquake is a complex and multivariate problem. Using a single parameter to extract anomalies is difficult to completely and truly reflect the preparation activity before earthquakes. In this paper, we develop a fusion anomaly extraction method based on principal component analysis (PCA) and non-negative tensor decomposition (NTD). It extracts anomalies by combining features of different parameters, which can obtain earthquake-related signals from dataset and reveal some weak anomalies hidden in individual parameters. By PCA-NTD, we fused the electron density and magnetic field data from the Swarm satellites to explore the possible precursors of 2021 M7.3 Maduo earthquake and compared the results with those of the single-parameter analyses. The cumulative value of fusion anomalies indicates two acceleration stages before the mainshock: from -51 to -24 days, following a sigmoid trend, and from -21 to the earthquake occurrence, following a power-law behavior. The second acceleration is more pronounced than the first one, and its critical point occurs near the date of the Maduo earthquake. Spatially, these anomalies are located around important fault zones (Altun fault, Jiali fault, and Red River fault) and the epicenter region, which likely reflect the northward stress and eastward stress experienced in the seismogenic area before the mainshock. As the earthquake approaches, the anomalies become more concentrated and closer to the impending epicenter. Furthermore, the ionospheric anomalies correspond well with the anomalous phenomena of lithospheric activity and atmospheric thermal radiation, which support a multi-channel lithosphere-atmosphere-ionosphere coupling (LAIC).
    Description: Published
    Description: 2002424
    Description: OST4 Descrizione in tempo reale del terremoto, del maremoto, loro predicibilità e impatto
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 4
    Publication Date: 2019
    Electronic ISSN: 2052-4463
    Topics: Nature of Science, Research, Systems of Higher Education, Museum Science
    Published by Springer Nature
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  • 5
    Publication Date: 2014-08-22
    Description: Background: Characterization of genome-wide patterns of allelic variation and linkage disequilibrium can be used to detect reliable phenotype?genotype associations and signatures of molecular selection. However, the use of Sesamum indicum germplasm for breeding is limited by the lack of polymorphism data. Results: Here we describe the massively parallel resequencing of 29 sesame strains from 12 countries at a depth of???13-fold coverage for each of the samples tested. We detected an average of 127,347 SNPs, 17,961 small InDels, and 9,266 structural variants per sample. The population SNP rate, population diversity (?) and Watterson?s estimator of segregating sites (?w) were estimated at 8.6???10-3, 2.5???10-3 and 3.0???10-3?bp-1, respectively. Of these SNPs, 23.2% were located within coding regions. Polymorphism patterns were nonrandom among gene families, with genes mediating interactions with the biotic or abiotic environment exhibiting high levels of polymorphism. The linkage disequilibrium (LD) decay distance was estimated at 150?kb, with no distinct structure observed in the population. Phylogenetic relationships between each of the 29 sesame strains were consistent with the hypothesis of sesame originating on the Indian subcontinent. In addition, we proposed novel roles for adenylate isopentenyltransferase (ITP) genes in determining the number of flowers per leaf axil of sesame by mediating zeatin biosynthesis. Conclusions: This study represents the first report of genome-wide patterns of genetic variation in sesame. The high LD distance and abundant polymorphisms described here increase our understanding of the forces shaping population-wide sequence variation in sesame and will be a valuable resource for future gene?phenotype and genome-wide association studies (GWAS).
    Electronic ISSN: 1471-2229
    Topics: Biology
    Published by BioMed Central
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  • 6
    Publication Date: 2017-12-07
    Description: IJERPH, Vol. 14, Pages 1522: Association of Social Support and Medication Adherence in Chinese Patients with Type 2 Diabetes Mellitus International Journal of Environmental Research and Public Health doi: 10.3390/ijerph14121522 Authors: Linni Gu Shaomin Wu Shuliang Zhao Huixuan Zhou Shengfa Zhang Min Gao Zhiyong Qu Weijun Zhang Donghua Tian The prevalence of diabetes is steadily increasing in China. When diabetes is uncontrolled, it generates dire consequences for health and well-being. Numerous studies have shown that health outcomes were associated with social support and medication adherence. Previous study confirmed that social support was associated with medication adherence in patients with heart failure, HIV diseases, and first-episode psychosis. However, the relationship between social support and medication adherence in patients with type 2 diabetes mellitus (T2DM) is remains unclear. This study aims to examine whether social support is associated with medication adherence in patients with T2DM. This study was conducted in the First Affiliated Hospital of the General Hospital of the People’s Liberation Army (PLA). In Beijing, a systematic random sample of 412 patients with T2DM over 18 years was recruited at baseline, and demographic characteristics, clinical data and their assessment of social support were collected from medical records and self-reported questionnaires. 330 of these patients completed a self-report measure of medication adherence at the sixth month after baseline data collection. Regression analysis showed that social support presented a positive effect on medication adherence, additionally, support utilization and the subscale of social support exhibited a significantly strong influence on medication adherence in patients with T2DM. Although medication adherence was influenced by multiple factors, this finding confirmed that social support must be recognized as a core element in interventions aimed at improving in the management of patients with T2DM.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by MDPI Publishing
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  • 7
    Publication Date: 2017-04-28
    Description: The “empty-nest” elderly family has become increasingly prevalent among old people in China. This study aimed to explore the causality between empty nests and elders’ health using effective instrumental variables, including “whether old parents talk with their families when they are upset” and “ownership of housing”. The results showed that empty nests had a significantly adverse influence on elders’ physical health, cognitive ability and psychological health. Furthermore, urban elders’ cognitive ability was more influenced by empty nests than that of rural elders. Additionally, the effects of an empty nest on elders” health were more significant among female, single elders and senior rural elders. “Living resources”, “availability of medical treatment” and “social activity engagement” were found to be significant mediators between empty nests and elders’ health, accounting for 35% of the total effect.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by MDPI Publishing
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  • 8
    Publication Date: 2016-05-01
    Print ISSN: 0264-1275
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Elsevier
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  • 9
    Publication Date: 2020-06-10
    Print ISSN: 2095-1701
    Electronic ISSN: 2095-1698
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Springer
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  • 10
    Publication Date: 2005-11-16
    Description: CML28 is a new tumor-associated antigen overexpressed in tumor cells, which is an attractive target for antigen-specific immunotherapy. In this study, we evaluated the possibility to induce CML28-specific cytotoxic T cells by cotransfection of CML28 nucleic acid vaccination and SOCS1-specific siRNA expression vector with dendritic cells in vitro. The full length CML28 cDNA was amplified from K562 by RT-PCR and cloned into a bicistronic vector pIRES2-EGFP to construct the CML28 nucleic acid vaccination. Dendritic cells (DCs) were generated from peripheral blood mononuclear cells (PBMNCs) of HLA-A2+ healthy donor. Construct the recombinant plasmid psiRNA-hH1neo-SOCS1 encoding hairpin small interfering RNA (siRNA) targeting to suppressors of cytokine signaling 1 (SOCS1) sequences using a vector-base RNA interference technology. Cotransfect CML28 nucleic acid vaccination and recombinant siRNA vector psiRNA-hH1neo-SOCS1 into DCs by electroporation. Real-time RT-PCR was performed to validate the SCOS1 gene silencing efficacy. The expression products of CML28 nucleic acid vaccination, His-CML28 fusion protein and GFP protein, were measured by Western Blotting and fluorescence microscope respectively. Labeling autologous nonadherent fraction of PBMNCs as responder cells by 5, 6-carboxyfluorescein diacetate succinimidyl ester (CFSE) firstly, and then coculture with cotransfected DCs for mixed lymphocyte reaction (MLR). Autogous T cell proliferative response of MLR was measured by FACS by detecting CFSE. Cotransfected DCs and the PBMNCs of a HLA-A2+ primary leukemia patient were used as target cells, untransfected DCs, K562 and HL60 were used as control. The standard 51Cr-release assay was performed to measure cytotoxicity of stimulated lyphocytes. CML28 nucleic acid vaccination could encode His-CML28 and GFP protein in DCs successfully. SOCS1-specific siRNA expression vector psiRNA-hH1neo-SOCS1 significantly suppress the expression of SOCS1 in DCs. Down regulation of SOCS1 resulted in higher expression level of CD80, CD86 and CD83 in cotranfected DCs and more rounds of cell division of responder cells in CFSE-MLR, which indicates SOCS1 gene silencing greatly contribute to maturation of DCs and enhance the the proliferative response of responder cells. CTLs induced by cotransfected DCs exhibit stronger CML28-specific cytotoxicity against HLA- matched target cells comparing to CTLs induced by CML28 nucleic acid vaccination transfected DCs only. SOCS1 gene silencing in DCs could greatly enhance the anti-tumor efficacy of CML28 nucleic acid vaccination. DCs cotransfected with CML28 nucleic acid vaccination and SOCS1-specific siRNA expression vector could effectively induce autologous CML28-specific cytotoxic T cells that lyse CML28 positive tumor cells in an antigen-specific and major histocompatibility complex (MHC) class I-restricted manner.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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