ISSN:
0899-0042
Keywords:
HPLC
;
chiral stationary phase
;
optical isomers
;
absolute configuration
;
circular dichroism
;
chiral
;
enantiomers
;
terfenadine
;
cyclodextrin
;
normal phase
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Enantiomers of terfenadine were resolved by high-performance liquid chromatography (HPLC) using a chiral stationary phase (CSP) column packed with β-cyclodextrin (β-CD) covalently bound to silica. Separation was achieved in both the reverse phase and normal phase modes. Resolution of enantiomers was confirmed by ultraviolet-visible absorption, circular dichroism, and mass spectral analysis.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.530040411
Permalink