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  • 1
    Publication Date: 2015-01-17
    Description: Our understanding of when and how humans adapted to living on the Tibetan Plateau at altitudes above 2000 to 3000 meters has been constrained by a paucity of archaeological data. Here we report data sets from the northeastern Tibetan Plateau indicating that the first villages were established only by 5200 calendar years before the present (cal yr B.P.). Using these data, we tested the hypothesis that a novel agropastoral economy facilitated year-round living at higher altitudes since 3600 cal yr B.P. This successful subsistence strategy facilitated the adaptation of farmers-herders to the challenges of global temperature decline during the late Holocene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, F H -- Dong, G H -- Zhang, D J -- Liu, X Y -- Jia, X -- An, C B -- Ma, M M -- Xie, Y W -- Barton, L -- Ren, X Y -- Zhao, Z J -- Wu, X H -- Jones, M K -- New York, N.Y. -- Science. 2015 Jan 16;347(6219):248-50. doi: 10.1126/science.1259172. Epub 2014 Nov 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Key Laboratory of Western China's Environmental Systems (Ministry of Education), Lanzhou University, Lanzhou 730000, China. fhchen@lzu.edu.cn ghdong@lzu.edu.cn. ; Key Laboratory of Western China's Environmental Systems (Ministry of Education), Lanzhou University, Lanzhou 730000, China. ; Department of Anthropology, Washington University in St. Louis, St. Louis, MO 63130-48, USA. ; Center for Comparative Archaeology, Department of Anthropology, University of Pittsburgh, Pittsburgh, PA 15260, USA. ; Qinghai Provincial Institute of Cultural Relics and Archaeology, Xining 810007, China. ; Institute of Archaeology, Chinese Academy of Social Sciences, Beijing 100710, China. ; School of Archaeology and Museology, Peking University, Beijing 100871, China. ; McDonald Institute of Archaeological Research, University of Cambridge, Cambridge CB2 3ER, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25593179" target="_blank"〉PubMed〈/a〉
    Keywords: Acclimatization ; Agriculture/*history ; *Altitude ; Archaeology ; Climate ; History, Ancient ; Humans ; Radiometric Dating ; Temperature ; Tibet
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2016-11-23
    Description: Author(s): J. G. Zheng, Y. D. Cui, Z. J. Zhao, J. Li, and B. C. Khoo A thorough combined numerical and experimental investigation of nanosecond dielectric barrier discharge actuation provides a description of the dynamics of the flow actuation process and elucidates the associated flow control mechanisms. [Phys. Rev. Fluids 1, 073501] Published Tue Nov 22, 2016
    Keywords: Flow control
    Electronic ISSN: 2469-990X
    Topics: Physics
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 12 (1989), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— Previous work has shown that a single tapered cylindrical specimen subjected to slow strain rate testing can provide data for the crack initiation stress of 70/30 brass in 1N NaNO2 solution. In order to test the wider applicability of that technique, crack initiation stresses of a further five systems were measured. These were 70/30 brass in an ammoniacal solution, copper in sodium nitrite and mild steel in carbonate–bicarbonate, hydroxide or nitrate solutions. The results are compared with those obtained from tests on plain cylindrical specimens subjected to interrupted slow strain rate tests or to constant load tests, and the agreement is reasonable. The method also is capable of providing data on the stress dependence of crack velocities.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 15 (1996), S. 1590-1591 
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 5
  • 6
    Publication Date: 2016-07-16
    Description: Cancer is often driven by the accumulation of genetic alterations, including single nucleotide variants, small insertions or deletions, gene fusions, copy-number variations, and large chromosomal rearrangements. Recent advances in next-generation sequencing technologies have helped investigators generate massive amounts of cancer genomic data and catalog somatic mutations in both common and rare cancer types. So far, the somatic mutation landscapes and signatures of 〉10 major cancer types have been reported; however, pinpointing driver mutations and cancer genes from millions of available cancer somatic mutations remains a monumental challenge. To tackle this important task, many methods and computational tools have been developed during the past several years and, thus, a review of its advances is urgently needed. Here, we first summarize the main features of these methods and tools for whole-exome, whole-genome and whole-transcriptome sequencing data. Then, we discuss major challenges like tumor intra-heterogeneity, tumor sample saturation and functionality of synonymous mutations in cancer, all of which may result in false-positive discoveries. Finally, we highlight new directions in studying regulatory roles of noncoding somatic mutations and quantitatively measuring circulating tumor DNA in cancer. This review may help investigators find an appropriate tool for detecting potential driver or actionable mutations in rapidly emerging precision cancer medicine.
    Print ISSN: 1467-5463
    Electronic ISSN: 1477-4054
    Topics: Biology , Computer Science
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  • 7
    Publication Date: 2013-10-02
    Description: The Shagou vein-type Ag-Pb-Zn deposit in the Xiong’ershan district, southern margin of the North China craton, is hosted within amphibolite facies metamorphic rocks of the Late Archean to early Paleoproterozoic Taihua Group. The Ag-Pb-Zn veins are localized in NE- to NNE-trending brittle faults and typically display symmetrical zoning consisting of siderite, quartz + sphalerite, galena, and quartz + calcite from the margin toward the center of each vein. Ore-related hydrothermal alteration is well developed on both sides of the veins, dominated by silicification, sericitization, chloritization, and carbonatization. Sericite separates extracted from a major Ag-Pb-Zn vein yield a 40 Ar/ 39 Ar plateau age of 140.0 ± 1.0 Ma (1 ) and isochron age of 141.1 ± 1.6 Ma (1 ), indicating that mineralization occurred at the beginning of Early Cretaceous. Field and textural relationships indicate four hydrothermal stages marked by assemblages of quartz + siderite (stage I), quartz + sphalerite + ankerite (stage II), quartz + galena + silver minerals + ankerite (stage III), and quartz + calcite (stage IV), respectively. Silver minerals are abundant in all veins and are composed of, in paragenetic order, argentiferous tetrahedrite, polybasite, jalpaite, argentite, and native silver. These silver minerals commonly occur as replacements of galena, chalcopyrite, and other sulfides, or as fillings of microfractures in sulfides and quartz. Microthermometric measurements of primary fluid inclusions in quartz, carbonates, and sphalerite from various hydrothermal stages indicate that ore minerals were deposited at intermediate temperatures (267°–157°C) from aqueous-carbonic to aqueous fluids with moderate salinities (7.2–15.9 wt % NaCl equiv). Coexisting galena-sphalerite pair yields sulfur isotope equilibrium temperatures of 205° to 267°C, consistent with the overall homogenization temperatures of fluid inclusions. The microthermometric data also indicate that both fluid mixing and fluid-rock interaction were important mechanisms for ore precipitation. Carbonate minerals (siderite, ankerite, calcite) spanning the entire mineralization history have 13 C V-PDB values of –5.2 to –1.4 and 18 O V-SMOW of 10.9 to 15.0, corresponding to calculated values for the ore fluids of –6.5 to –1.8 and 1.4 to 5.4, respectively. 34 S V-CDT values of sulfide minerals (pyrite, sphalerite, galena) range from 1.1 to 5.5, consistent with a deep-seated sulfur source. Galena separates have 206 Pb/ 204 Pb ratios of 17.472 to 17.813, 207 Pb/ 204 Pb ratios of 15.411 to 15.498, and 208 Pb/ 204 Pb ratios of 38.178 to 38.506. The isotope data, together with geological and geochronological evidence, favor a primary metamorphic source for sulfur and other components in the ore fluids. A synthesis of available data suggests that the Shagou deposit is a typical vein-type Ag-Pb-Zn deposit that formed under an extensional geodynamic setting associated with tectonic reactivation of the North China craton during the late Mesozoic, a time period that is manifested by pervasive magmatism, widespread formation of metamorphic core complexes, and development of faulted basins throughout the eastern part of the craton. Metamorphic devolatilization of the Meso-Neoproterozoic marine sedimentary rocks previously subducted beneath the Xiong’ershan district, facilitated by extensive magmatism and elevated heat flow due to lithospheric extension, could have provided large amounts of ore fluids responsible for the Ag-Pb-Zn mineralization. The NE- to NNE-trending faults affiliated with the transcrustal Machaoying fault may have acted as pathways for the upward migration of deep-seated metamorphic fluids. Mixing of the metamorphically derived fluids with meteoric waters ultimately resulted in deposition of the Ag-Pb-Zn veins in brittle extensional structures.
    Print ISSN: 0361-0128
    Topics: Geosciences
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  • 8
    Publication Date: 2013-04-10
    Description: To define genetic lesions driving leukemia, we targeted cre-dependent Sleeping Beauty (SB) transposon mutagenesis to the blood-forming system using a hematopoietic-selective vav 1 oncogene (vav1) promoter. Leukemias of diverse lineages ensued, most commonly lymphoid leukemia and erythroleukemia. The inclusion of a transgenic allele of Janus kinase 2 (JAK2)V617F resulted in...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 9
    Publication Date: 2016-01-07
    Description: Tumor suppressor genes (TSGs) are a major type of gatekeeper genes in the cell growth. A knowledgebase with the systematic collection and curation of TSGs in multiple cancer types is critically important for further studying their biological functions as well as for developing therapeutic strategies. Since its development in 2012, the Tumor Suppressor Gene database (TSGene), has become a popular resource in the cancer research community. Here, we reported the TSGene version 2.0, which has substantial updates of contents (e.g. up-to-date literature and pan-cancer genomic data collection and curation), data types (noncoding RNAs and protein-coding genes) and content accessibility. Specifically, the current TSGene 2.0 contains 1217 human TSGs (1018 protein-coding and 199 non-coding genes) curated from over 9000 articles. Additionally, TSGene 2.0 provides thousands of expression and mutation patterns derived from pan-cancer data of The Cancer Genome Atlas. A new web interface is available at http://bioinfo.mc.vanderbilt.edu/TSGene/ . Systematic analyses of 199 non-coding TSGs provide numerous cancer-specific non-coding mutational events for further screening and clinical use. Intriguingly, we identified 49 protein-coding TSGs that were consistently down-regulated in 11 cancer types. In summary, TSGene 2.0, which is the only available database for TSGs, provides the most updated TSGs and their features in pan-cancer.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 10
    Publication Date: 2005-05-15
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
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