Publication Date:
1988-08-19
Description:
N-Methyl-D-aspartate (NMDA), phencyclidine (PCP), and quisqualate receptor binding were compared to benzodiazepine, gamma-aminobutyric acid (GABA), and muscarinic cholinergic receptor binding in the putamen and cerebral cortex of individuals with Huntington's disease (HD). NMDA receptor binding was reduced by 93 percent in putamen from HD brains compared to binding in normal brains. Quisqualate and PCP receptor binding were reduced by 67 percent, and the binding to other receptors was reduced by 55 percent or less. Binding to these receptors in the cerebral cortex was unchanged in HD brains. The results support the hypothesis that NMDA receptor-mediated neurotoxicity plays a role in the pathophysiology of Huntington's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, A B -- Greenamyre, J T -- Hollingsworth, Z -- Albin, R -- D'Amato, C -- Shoulson, I -- Penney, J B -- NS15655/NS/NINDS NIH HHS/ -- NS17978/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1988 Aug 19;241(4868):981-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, University of Michigan, Ann Arbor 48109.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2841762" target="_blank"〉PubMed〈/a〉
Keywords:
Cerebral Cortex/analysis/metabolism
;
Humans
;
Huntington Disease/*metabolism
;
Putamen/analysis/*metabolism
;
Receptors, AMPA
;
Receptors, Drug/analysis/metabolism
;
Receptors, GABA-A/analysis/metabolism
;
Receptors, Muscarinic/analysis/metabolism
;
Receptors, N-Methyl-D-Aspartate
;
Receptors, Neurotransmitter/*analysis/metabolism
;
Receptors, Phencyclidine
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink