Publication Date:
2014-12-12
Description:
Article Activating mutations of the tyrosine kinase Kit are commonly found in mast cell neoplasms and gastrointestinal stromal tumours. Here the authors show that mutant Kit, through the activation of PI3K and STAT3 pathways, elicits proliferative and survival signals from endolysosomes and from the endoplasmic reticulum. Nature Communications doi: 10.1038/ncomms6715 Authors: Yuuki Obata, Shota Toyoshima, Ei Wakamatsu, Shunichi Suzuki, Shuhei Ogawa, Hiroyasu Esumi, Ryo Abe
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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