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  • 1
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 288-289 (June 2005), p. 147-150 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In this study, we constructed a novel drug delivery system for realizing the combination of gene therapy and chemotherapy by co-loading 5-FU and antisense EGFR (epidermal growth factor receptor) plasmids in biodegradable PLGA/O-CMC (O-carboxmethyl-chitosan) nanoparticles. This novel kind of nanoparticle was characterized by dynamic light scattering for size, size distribution and zeta potential, and scanning electron microscopy (SEM) and transmission electronic microscopy (TEM) for morphological properties and structures. Drug encapsulation efficiency and drug release kinetics under in vitro conditions were also measured. At the same time, the MTT assay, the TUNEL technique and immunohistochemical staining were used to investigate the antitumor activity of these multi-functional nanoparticles on human glioma cells. It was concluded that the 5-FU and plasmid encapsulation efficiencies were as high as 94.5% and 95.7%, and the 5-FU release activity from nanoparticles could be sustained for as long as three weeks. Both the MTT assay and the TUNEL method illustrated that these multi-functional nanoparticles had cytotoxicities as high as 93.5% and could induce apoptosis in most glioma cells. Immunohistochemical staining proved that plasmids on the surface of nanoparticles could transfect gliomas cells, verified by a decline in the expression level of EGFR protein by the glioma cells. Therefore, this novel delivery system for drugs and genes provides another therapeutic pathway for cancer and needs further research
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Applied mathematics and mechanics 8 (1987), S. 147-154 
    ISSN: 1573-2754
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract In this paper we extend the method which Liu Zheng-rong provided to the weak-nonlinear partial equation with δ-function.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Applied mathematics and mechanics 2 (1981), S. 365-374 
    ISSN: 1573-2754
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract The bending problems of nonuniform beams with variable cross-section can be approximated by that of a step beam under sectionally uniform load (including both concentrated forces and couples). In this paper, the concept of Heaviside function {x−a}0 will be generalized, and a new function {x−a}n,n=0, 1, 2..., will be defined, which may be named as a generalized step function. The rules of operation will also be given to {x−a}n{x−b}0. The reciprocal of the flexural of rigidity 1/EJ and the bending momentM(x) can all be expressed in terms of {x−a}n, and substituted into the differential equation of the elastic curve of the beam respectively. Thus we may establish a set of unified method to solve various types of bending problems of straight beams. The general solution of the deflection equation will be given.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Applied mathematics and mechanics 14 (1993), S. 381-384 
    ISSN: 1573-2754
    Keywords: Brusselator ; limit cycle ; asymptotic solution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract In this paper, two kinds of asymptotic analytic expression of the Brusselator limit cycle are given by means of two simple methods. To some extent, they are better than the analytic expression in [2].
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Applied mathematics and mechanics 15 (1994), S. 571-578 
    ISSN: 1573-2754
    Keywords: attractor ; uniform absorbing set ; fractal dimension ; dissipative solition equation ; squeezing property and invariant cone property
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract In the paper, we study longtime dynamic behavior of dissipative soliton equation: existence of attractor, geometrical structure of attractor, dynamic behavior under the parametric perturbation of dissipative soliton equation, estimate of fractal dimension of attractor.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Applied mathematics and mechanics 8 (1987), S. 427-431 
    ISSN: 1573-2754
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract In this paper the situation in which weak spring Duffing equation gets into the chaos on account of small perturbation is discussed with Melnikov-Holmes' method, and some phenomena in which the different subharmonic and the ultrasubharmonic coexist with the chaos are discovered.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Applied mathematics and mechanics 9 (1988), S. 1121-1129 
    ISSN: 1573-2754
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract In this paper we give the relationship between Melnikov function and Poincaré map. and a new proof for Melnikov's method. The advantage of our paper is to give a more explicit solution and to make Melnikov function for the subharmonics bifurcation and Melnikov function which the stable manifolds and unstable manifolds intersect transversely into a formula.
    Type of Medium: Electronic Resource
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  • 8
    Publication Date: 2022-05-26
    Description: © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Yuan, X., Ummenhofer, C. C., Seo, H., & Su, Z. Relative contributions of heat flux and wind stress on the spatiotemporal upper-ocean variability in the tropical Indian Ocean. Environmental Research Letters, 15(8), (2020): 084047, doi:10.1088/1748-9326/ab9f7f.
    Description: High-resolution ocean general circulation model (OGCM) simulations are employed to investigate interannual variability of the upper-ocean temperature in the tropical Indian Ocean (20°S–20°N). The seasonal cycle and interannual variability in the upper-ocean temperature in the tropical Indian Ocean in the forced ocean simulation are in good agreement with available observation and reanalysis products. Two further sensitivity OGCM simulations are used to separate the relative contributions of heat flux and wind stress. The comparison of the model simulations reveals the depth-dependent influences of heat flux and wind stress on the ocean temperature variability in the tropical Indian Ocean. Generally, heat flux dominates the temperature variability in the top 30 m, while wind stress contributes most strongly to the subsurface temperature variability below 30 m. This implies that a transition depth should exist at each location, where the dominant control of the ocean temperature variability switched from heat flux to wind stress. We define the depth of this transition point as the 'crossing depth' and make use of this concept to better understand the depth-dependent impacts of the heat flux and wind stress on the upper-ocean temperature variability in the tropical Indian Ocean. The crossing depth tends to be shallower in the southern tropical Indian Ocean (20°S-EQ), including the Seychelles-Chagos Thermocline Ridge (SCTR) and the eastern part of the Indian Ocean Dipole (IOD), suggesting the dominance of forcing due to wind stress and the resulting ocean dynamical processes in the temperature variability in those regions. The crossing depth also shows prominent seasonal variability in the southern tropical Indian Ocean. In the SCTR, the variability of the subsurface temperature forced by the wind stress dominates largely in boreal winter and spring, resulting in the shallow crossing depth in these seasons. In contrast, the intensified subsurface temperature variability with shallow crossing depth in the eastern part of the IOD is seen during boreal autumn. Overall, our results suggest that the two regions within the tropical Indian Ocean, the SCTR and the eastern part of the IOD, are the primary locations where the ocean dynamics due to wind-stress forcing control the upper-ocean temperature variability.
    Description: This research was supported by a Research Fellowship by the Alexander von Humboldt Foundation to CCU. HS is grateful for support by ONR (N00014-17-1-2398) and NOAA (NA17OAR4310255).
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 9
    Publication Date: 2013-01-23
    Print ISSN: 1550-7998
    Electronic ISSN: 1550-2368
    Topics: Physics
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  • 10
    Publication Date: 2012-12-03
    Print ISSN: 1550-7998
    Electronic ISSN: 1550-2368
    Topics: Physics
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