ALBERT

Description: Remote Sensing, Vol. 9, Pages 1194: The 2015–2016 Ground Displacements of the Shanghai Coastal Area Inferred from a Combined COSMO-SkyMed/Sentinel-1 DInSAR Analysis Remote Sensing doi: 10.3390/rs9111194 Authors: Lei Yu Tianliang Yang Qing Zhao Min Liu Antonio Pepe In this work, ground deformation of the Shanghai coastal area is inferred by using the multiple-satellite Differential Synthetic Aperture Radar interferometry (DInSAR) approach, also known as the minimum acceleration (MinA) combination algorithm. The MinA technique allows discrimination and time-evolution monitoring of the inherent two-dimensional components (i.e., with respect to east-west and up-down directions) of the ongoing deformation processes. It represents an effective post-processing tool that allows an easy combination of preliminarily-retrieved multiple-satellite Line-Of-Sight-projected displacement time-series, obtained by using one (or more) of the currently available multi-pass DInSAR toolboxes. Specifically, in our work, the well-known small baseline subset (SBAS) algorithm has been exploited to recover LOS deformation time-series from two sets of Synthetic Aperture Radar (SAR) data relevant to the coast of Shanghai, collected from 2014 to 2017 by the COSMO-SkyMed (CSK) and the Sentinel-1A (S1-A) sensors. The achieved results evidence that the Shanghai ocean-reclaimed areas were still subject to residual deformations in 2016, with maximum subsidence rates of about 30 mm/year. Moreover, the investigation has revealed that the detected deformations are predominantly vertical, whereas the east-west deformations are less significant.

Description: Aims To explore molecular mechanisms that link peri-implantitis and type 2 diabetes mellitus (T2DM) by bioinformatic analysis of publicly available experimental transcriptomic data. Materials and methods Gene expression data from peri-implantitis were downloaded from the Gene Expression Omnibus database, integrated and differentially expressed genes (DEGs) in peri-implantitis were identified. Next, experimentally validated and computationally predicted genes related to T2DM were downloaded from the DisGeNET database. Protein–protein interaction network (PPI) pairs of DEGs related to peri-implantitis and T2DM related genes were constructed, “hub” genes and overlapping DEG were determined. Functional enrichment analysis was used to identify significant shared biological processes and signaling pathways. The PPI networks were subjected to cluster and specific class analysis for identifying “leader” genes. Module network analysis of the merged PPI network identified common or cross-talk genes connecting the two networks. Results A total of 92 DEGs overlapped between peri-implantitis and T2DM datasets. Three hub genes (IL-6, NFKB1, and PIK3CG) had the highest degree in PPI networks of both peri-implantitis and T2DM. Three leader genes (PSMD10, SOS1, WASF3), eight cross-talk genes (PSMD10, PSMD6, EIF2S1, GSTP1, DNAJC3, SEC61A1, MAPT, and NME1), and one signaling pathway (IL-17 signaling) emerged as peri-implantitis and T2DM linkage mechanisms. Conclusions Exploration of available transcriptomic datasets revealed IL-6, NFKB1, and PIK3CG expression along with the IL-17 signaling pathway as top candidate molecular linkage mechanisms between peri-implantitis and T2DM.