Publication Date:
2014-01-18
Description:
A simple and highly efficient stereoselective total synthesis of the 6-alkylated pyranones (6 R )-6-[(1 E ,4 R ,6 R )-4,6-dihydroxy-10-phenyldec-1-en-1-yl]-5,6-dihydro-2 H -pyran-2-one ( 1 ) and (6 S )-5,6-dihydro-6-[(2 R )-2-hydroxy-6-phenylhexyl]-2 H -pyran-2-one ( 2 ) was developed using Crimmins ' aldol reaction, SmI 2 reduction, Grubbs - II -catalyzed olefin cross-metathesis, and Still 's modified Horner Wadsworth Emmons reaction.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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