ISSN:
1573-8221
Keywords:
alpha-fetoprotein
;
natural tolerance
;
inhibition of macrophage migration reaction
;
antibody formation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The method of inhibition of macrophage migration (IMM) was used to study the state of cellular immunity after immunization of rats with cross-reacting mouse alpha-fetoprotein (MAFP). After a single injection of MAFP into the animals, peritoneal, exudate cells became capable of inducing the IMM reaction on incubation both with MAFP and also with homologous rat AFP (RAFP). Repeated injection of MAFP weakens the IMM response to both proteins and leads to stimulation of macrophage migration, coupled with a further increase in the titer of antibodies, against MAFP and RAFP. Fractionation of peritoneal cells showed that the IMM reaction to MAFP and RAFP is produced by T lymphocytes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00799801
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