ISSN:
0947-6539
Keywords:
carbasugars
;
cyclitols
;
enzyme inhibitors
;
salbostain
;
total syntheses
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The total synthesis of trehalase inhibitor salbostatin (1), recently discovered as a novel metabolite of Streptomyces albus species, has been achieved starting from the major product (58 % yield) from the coupling of the amine di-O-isopropylidene-α-valienamine and the electrophile 1,5 : 2,3-dianhydro-D-mannitol in 2-propanol. Deprotection with aqueous acetic acid and subsequent purification on a column of acidic resin afforded 1, which showed inhibitory activity (IC50 = 8.3 μML-1) against silkworm trehalase.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chem.19950010911
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