ISSN:
1573-8744
Keywords:
erythromycin stearate tablets
;
bioequivalence studies
;
absorption
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The bioequivalence of film-coated erythromycin stearate tablets produced by five different manufacturers was evaluated in a balanced incomplete block design involving the five formulations given to 30 fasted subjects over a 3-week study period. Serum levels of erythromycin activity were determined microbiologically. Statistical analysis of variance was performed on the observed bioavailability parameters: maximum serum concentration Cmax, time to maximum serum concentration (tmax), and area under the serum concentrationtime curve (AUC). There was no statistical difference between formulations for the tmax parameter. Formulation differences were found, however, based on the analysis of variance of the Cmax and AUC parameters. Two products, although not significantly different from one another, showed significantly greater Cmax and AUC values than the other three products.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01062534
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