Publication Date:
2011-05-11
Description:
Four new polyketides, botryosphaerones A–D ( 1 – 4 , resp.), were obtained from the fermentation culture of Botryosphaeria australis strain ZJ12-1A, together with four known compounds, O -methylasparvenone ( 5 ), 6-ethyl-2,7-dimethoxyjuglon ( 6 ) and its monoacetyl derivative 7 , and O -methylaspmenone ( 8 ). Their structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR experiments, and HR-Q-TOF mass spectrometry, and by comparison with reported data. All compounds were evaluated for their cytotoxic and antimicrobial activities in vitro. Only compounds 6 and 7 showed cytotoxic and antimicrobial activities, as already reported.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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