ISSN:
1432-1432
Keywords:
Key words: Transmembrane 4 superfamily — YKK8 —Caenorhabditis elegans
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract. Transmembrane 4 superfamily (TM4SF) molecules are predominantly mammalian cell surface glycoproteins that are thought to transduce signals mediating cell development, activation, and motility. Analysis of the Genpept sequence database reveals YKK8, a novel member of the TM4SF in the nematode, Caenorhabditis elegans. YKK8 is a putative 27.4-kDa protein encoded by a gene on chromosome III of the C. elegans genome (Wilson et al. [1994] Nature 368:32–38). The assignment of YKK8 to the TM4SF is justified by three criteria: statistical comparison of protein sequences, conserved TM4SF protein sequence motifs, and conserved TM4SF intron/exon boundaries in the genomic sequence. The discovery of a TM4SF molecule in the nematode extends this superfamily to a more primitive branch of the phylogenetic tree and suggests a fundamental role for TM4SF molecules in biology.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00013140
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