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  • 1
    Electronic Resource
    Electronic Resource
    Dietary Fish Oil Supplementation Adversely Affects Cortical Bone Morphology and Biomechanics in Growing Rabbits (2000)
    Springer
    Calcified tissue international 66 (2000), S. 443-448 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Fish oil — Cortical bone — Energy restriction — Bone growth — Rabbits.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Despite substantial evidence that fish oil-derived (n-3) polyunsaturated fatty acids (PUFA) may protect against cardiovascular disease, the effects of supplements containing (n-3) PUFA on the skeletal system are unknown. Here we investigated how a diet supplemented with 10 g/100 g fish oil affected tibial cortical morphology and mechanical properties in weanling rabbits. Rabbits were subdivided into a normal control (n = 10), a fish oil (n = 20), and a pair-fed (n = 20) group. The pair-fed group was energy restricted to match average body mass of the fish oil group. At completion of the 40 day dietary intervention, control rabbits were significantly heavier than the other two groups. Comparison between control and pair-fed rabbits revealed that energy restriction alone (30%) did not induce significant changes in tibial middiaphyseal morphology, but tibial longitudinal growth was significantly impaired. Most tibial mechanical properties were significantly degraded by energy restriction. Fish oil-supplemented rabbits had significantly smaller middiaphyseal areal properties and shorter tibiae than pair-fed rabbits. Tibial structural properties were significantly reduced in fish oil-fed rabbits, but tibial stress at the proportional limit (material property) was not significantly affected. Our data suggest that 10% fish oil supplementation in the presence of modest vitamin E supplementation can have detrimental effects on the skeleton of rapidly growing rabbits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002230010089
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of High-Fat Diet on Mature Bone Mineral Content, Structure, and Mechanical Properties (1998)
    Springer
    Calcified tissue international 63 (1998), S. 74-79 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Saturated fat — Bone mechanics — Cortical bone — Cancellous bone — Osteoporosis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Diets with a high saturated fat content can produce deleterious effects on the absorption of dietary calcium and consequently an adverse effect on bone mineralization in growing animals. Hence dietary fat may have long-term consequences for skeletal health and skeletal pathologies such as osteoporosis. Whether a diet high in saturated fat has similar negative effects on adult bone, however, remains unresolved. Thus, we investigated effects of a high-fat diet on mature bone structure and mechanics. Adult (40-week-old) roosters were maintained for 20 weeks on either a diet high in saturated fat (HF) or a low-fat (LF) diet. Cortical bone samples (tarsometatarsus) were tested mechanically in three-point bending, and cancellous bone cores from the femoral condyles and tibial plateau (four sites per knee) were tested mechanically in compression. Cortical bone cross-sectional areal data were also compared among the groups, and bone mineral content (BMC) was determined (by ashing) for both cortical bone and cancellous bone samples. There were no significant high-fat diet effects on mature cortical bone mechanical properties, geometric structure, or mineral content. Diet, however, did affect cancellous bone composition. For example, LF cancellous BMC was significantly greater than HF. Mechanical properties of the cancellous bone showed similar trends such that LF cancellous bone strength was consistently greater than HF. The potential for adverse effects of a HF diet on intestinal calcium absorption in the mature animal may be more apparent in cancellous bone, with its faster rate of turnover, than in cortical bone. Changes in cancellous bone structure and mechanical properties, related to dietary saturated fats, may have implications for understanding the role of nutrition in skeletal health and prevention of pathological bone loss (osteoporosis).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900492
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