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  • 1
    Electronic Resource
    Electronic Resource
    Physical association of a DNA polymerase stimulating activity with a ribonuclease H purified from yeast (1983)
    s.l. : American Chemical Society
    Biochemistry 22 (1983), S. 5500-5507 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00293a008
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  • 2
    Electronic Resource
    Electronic Resource
    The nuclear actin-related protein Act3p/Arp4p of Saccharomyces cerevisiae is involved in transcription regulation of stress genes (2003)
    Oxford, UK : Blackwell Publishing Ltd.
    Molecular microbiology 50 (2003), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: A mutational analysis of the essential nuclear actin-related protein of Saccharomyces cerevisiae, Act3p/Arp4p, was performed. The five residues chosen for substitution were amino acids conserved between actin and Act3p/Arp4p, the tertiary structure of which most probably resembles that of actin. Two thermosensitive (ts) mutants, a single and a double point mutant, and one lethal double point mutant were obtained. Both ts mutants were formamide-sensitive which supports a structural relatedness of Act3p/Arp4p to actin; they were also hypersensitive against hydroxyurea and ultraviolet irradiation pointing to a possible role of Act3p/Arp4p in DNA replication and repair. Their ‘suppressor of Ty’ (SPT) phenotype, ob-served with another ts mutant of Act3p/Arp4p before, suggested involvement of Act3p/Arp4p in transcription regulation. Accordingly, genome-wide expression profiling revealed misregulated transcription in a ts mutant of a number of genes, among which increased expression of various stress-responsive genes (many of them requiring Msn2p/Msn4p for induction) was the most salient result. This provides an explanation for the mutant's enhanced resistance to severe thermal and oxidative stress. Thus, Act3p/Arp4p takes an important part in the repression of stress-induced genes under non-stress conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.2003.03759.x
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  • 3
    Electronic Resource
    Electronic Resource
    Yeast-Mating-Type Switching: A Model System for the Study of Genome Rearrangements Induced by Carcinogens (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 534 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb30142.x
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  • 4
    Electronic Resource
    Electronic Resource
    Investment in UK universities (1990)
    [s.l.] : Nature Publishing Group
    Nature 348 (1990), S. 577-577 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR -Infante and Huszagh1 rightly complain about the now prevailing phenotype among researchers in biology; they describe it as poorly imaginative, lacking scepticism and creativity, but one that is productive in getting data published. They note that "there seem to be fewer and fewer people able ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/348577c0
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  • 5
    Electronic Resource
    Electronic Resource
    Determination of mating-type conversion rates of heterothallic Saccharomyces cerevisiae with the fluctuation assay (1988)
    Springer
    Current genetics 14 (1988), S. 355-362 
    Details
    ISSN: 1432-0983
    Keywords: S. cerevisiae ; Mating type switching ; Fluctuation assay ; Na-butyrate ; Intrachromosomal gene conversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The fluctuation assay of Luria and Delbrück was adapted for the exact determination of mating-type interconversion rates of semi-sterile heterothallic strains of Saccharomyces cereviae. These rates varied between 10−7 and 10−6, depending on the individual strain, and were enhanced in a dose-dependent manner for cells growing in the presence of increasing concentrations of sodium butyrate. Under our experimental conditions, the distribution of alpha cells over populations of a(ste2) cells corresponded to a Poissonian distribution (within sample errors); that over populations of a(ste14)-cells did not differ significantly from the distribution calculated by Lea and Coulsen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00419993
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  • 6
    Electronic Resource
    Electronic Resource
    Starvation for a specific amino acid induces high frequencies of rho− mutants in Saccharomyces cerevisiae (1997)
    Springer
    Current genetics 31 (1997), S. 408-413 
    Details
    ISSN: 1432-0983
    Keywords: Key words Starvation  ;  Petite  ;  Adaptive mutation  ;  Respiratory deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Auxotrophic yeast cells were starved on solid media for their respective essential amino acid in the course of “adaptive mutation” experiments. Thereby, high proportions of mitochondrially respiratory deficient (rho−) mutants accumulated among the cells stressed on selective plates. Using a strain with a plus-four frameshift mutation in a chromosomal gene involved in lysine biosynthesis, we observed that many of the revertant colonies which arose late under the selective pressure were composed of mixtures of rho+ and rho− cells, indicating that they originated from founder cells containing intact as well as defective mitochondrial genomes. We show that in spite of the slower growth of rho− cells the late-appearing colonies cannot be interpreted as descending from rho− revertants present before selective plating.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002940050223
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  • 7
    Electronic Resource
    Electronic Resource
    Chemical carcinogenesis — the price for DNA-repair? (1982)
    Springer
    Naturwissenschaften 69 (1982), S. 107-113 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Notes: Abstract This essay examines the possibility of merging the mutation theory of cancer with the hypothesis that cancer is a change in the state of the differentiation of cells. It is suggested that during normal development DNA rearrangements occur, concerning genes which code for differentiation specific cell communication proteins. These proteins are responsible for the proper functioning of growth control in a multicellular organism. DNA-damaging agents — mutagens — induce DNA repair enzymes, some of which may catalyse illegitimate genome rearrangements, thus leading to a change of the balance between growth and differentiation. A cell with a selective advantage may arise and become the origin of a tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00376714
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  • 8
    Electronic Resource
    Electronic Resource
    Replication-dependent and selection-induced mutations in respiration-competent and respiration-deficient strains of Saccharomyces cerevisiae (1998)
    Springer
    Molecular genetics and genomics 260 (1998), S. 395-400 
    Details
    ISSN: 1617-4623
    Keywords: Key words Replication-independent mutation ; Petite ; Starvation-associated mutation ; Hypermutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Adaptive or selection-induced mutations are defined as mutations that occur in non-dividing cells as a response to prolonged non-lethal selective pressure such as starvation for an essential amino acid. In the absence of DNA replication, the processing of endogenous DNA lesions by repair enzymes probably acts as a source of mutations. We are studying selection-induced reversions of frameshift alleles in the eukaryote Saccharomyces cerevisiae. Here we show that respiration-deficient strains, totally devoid of mitochondrial DNA, yield selection-induced mutants at slightly elevated frequencies compared to isonucleic respiration-competent strains. Therefore factors of mitochondrial origin such as reactive oxygen species or hypothetical recombinogenic DNA fragments are unlikely to be mediators of selection-induced nuclear frameshift mutation in yeast. Furthermore we compared sequence spectra of reversions of the +1 hom3-10 frameshift allele and found a strong preference for −1 deletions in mononucleotide repeats in selection-induced and replication-dependent revertants, indicating slippage errors during DNA repair synthesis as well as during DNA replication. Remarkably, a higher degree of variation in the site of the reverting frameshift and accompanying base substitutions was found among selection-induced revertants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380050909
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  • 9
    Electronic Resource
    Electronic Resource
    Induction of cytoplasmic respiratory deficient mutants in yeast by the folic acid analogue, methotrexate (1973)
    Springer
    Molecular genetics and genomics 126 (1973), S. 71-74 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The respiratory deficient mutants induced by methotrexate are shown by genetic analysis to be cytoplasmic petites of both neutral and suppressive types. Mitochondrial DNA is shown to be present in the suppressive mutants tested while in the neutral petites, DNA was only detected in one case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333483
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  • 10
    Electronic Resource
    Electronic Resource
    Induction of cytoplasmic respiratory deficient mutants in yeast by the folic acid analogue, methotrexate (1973)
    Springer
    Molecular genetics and genomics 126 (1973), S. 61-70 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The folic acid analogue, methotrexate, was found to be an effective inducer of the cytoplasmic petite mutation in different strains of S. carlsbergensis and S. cerevisiae. The induction varies considerably from strain to strain and also with growth conditions under which the experiments are carried out. Determination of mitochondrial protein synthesis in the presence of methotrexate shows a considerable decrease in incorporation of radioactive leucine before any significant induction of petites has taken place. These results and a comparison with results from other laboratories obtained with different drugs provide the basis for a proposed mechanism of petite induction by methotrexate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333482
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