Publication Date:
2020-05-29
Description:
The Pioneer 100 Wellness Project involved quantitatively profiling 108 participants’ molecular physiology over time, including genomes, gut microbiomes, blood metabolomes, blood proteomes, clinical chemistries, and data from wearable devices. Here, we present a longitudinal analysis focused specifically around the Pioneer 100 gut microbiomes. We distinguished a subpopulation of individuals with reduced gut diversity, elevated relative abundance of the genusPrevotella, and reduced levels of the genusBacteroides. We found that the relative abundances ofBacteroidesandPrevotellawere significantly correlated with certain serum metabolites, including omega-6 fatty acids. Primary dimensions in distance-based redundancy analysis of clinical chemistries explained 18.5% of the variance in bacterial community composition, and revealed aBacteroides/Prevotelladichotomy aligned with inflammation and dietary markers. Finally, longitudinal analysis of gut microbiome dynamics within individuals showed that direct transitions betweenBacteroides-dominated andPrevotella-dominated communities were rare, suggesting the presence of a barrier between these states. One implication is that interventions seeking to transition betweenBacteroides- andPrevotella-dominated communities will need to identify permissible paths through ecological state-space that circumvent this apparent barrier.
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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