ISSN:
1573-904X
Keywords:
cefsulodin
;
cefmenoxime
;
cefadroxil
;
residues on surfaces
;
high-performance liquid chromatography
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Cefsulodin, cefmenoxime, and cefadroxil are degraded instantaneously in aqueous sodium hypochlorite, sodium hypochlorite-detergent, or alkaline detergent solutions. These alkaline solutions are used to clean surfaces that have been exposed to the cephalosporins. The cleaned surfaces are monitored for residual drug levels (microgram) using a wet swab–dry swab technique. After extraction from the swabs, the content of the respective cephalosporin is determined in the solution by high-performance liquid chromatography. The limit of detection for each of the compounds is 0.1 µg/ml. Recoveries from nonporous surfaces ranged from 56 to 102%.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015850517994
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