Publication Date:
2012-10-10
Description:
Proteinase-Activated rreceptor-2 (PAR2), a G-protein–coupled Receptor, activated by serine proteinases, is reported to have both protective and proinflammatory effects in the airway. Given these opposing actions, both inhibitors and activators of PAR2 have been proposed for treating asthma. PAR2 can signal through two independent pathways: a β-arrestin–dependent one that promotes...
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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