ISSN:
1420-9071
Keywords:
Dihydroergotamine
;
endothelial cells
;
smooth muscle cell
;
prostanoid production
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The most important effect of dihydroergotamine is venoconstriction, but certain metabolic effects and changes in vessel prostanoid activity have also been suggested. In this study endothelial cell production of 6-keto PGF1α and TxB2 was quantitated in vitro. No evidence of altered prostanoid production was noted after incubation with dihydroergotamine (exposure ranging from 5×10−3 to 5×10−7 g/l). Similarly, no effect of dihydroergotamine on the growth rates of endothelial cells or smooth muscle cells in vitro was documented.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01941713
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