ISSN:
1434-193X
Keywords:
Chondromycesspec.
;
Myxobacteria
;
Antibiotics
;
Fungicides
;
Structure elucidation
;
Relative configuration
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
-Four novel antifungal and highly cytotoxic metabolites, the crocacins A-D (1-4), were isolated in our screening of the myxobacterial genus Chondromyces from strains of C. crocatus and C. pediculatus. Crocacin A, B, and D (1, 2, and 4) are unusual dipeptides of glycine and a 6-aminohexenoic or -hexadienoic acid, which is N-protected by a complex polyketide-derived acyl residue. The latter is a multiply substituted phenylundecatrienoic acid, which is found as its primary amide crocacin C (3). Based on 1H coupling constants, NOEs and MM+ calculations the relative configuration of the asymmetric centers and their preferred conformation are proposed for the crocacins.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
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