Publication Date:
1981-01-30
Description:
Growth of mouse lymphoma L5178Y, which contains large quantitites of the gangliotriosylceramide (GgOs3Cer), in DBA/2 mice was suppressed by passive immunization with monoclonal immunoglobulin G3 antibodies to GgOS3Cer, but not by immunoglobulin M antibodies with or without added complement. Most groups of mice treated with monoclonal immunoglobulin G3 antibodies did not develop tumors, but the tumor that appeared in a treated animal had a much lower amount of the GgOS3Cer than the cells used for inoculation. Thus, passive immunization either prevented growth of the lymphoma or caused selection of a variant with a lower quantity of the antigen GgOS3Cer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, W W Jr -- Hakomori, S I -- CA27746/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):487-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7455688" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, Neoplasm
;
Antigens, Surface
;
Clone Cells/immunology
;
Glycolipids/*immunology
;
Hybrid Cells/immunology
;
Immunization, Passive
;
Immunoglobulin G/administration & dosage
;
Immunoglobulin M/administration & dosage
;
Immunotherapy
;
Lymphoma/immunology/*therapy
;
Mice
;
Neoplasms, Experimental/therapy
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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