Publication Date:
1984-06-29
Description:
Corticotropin-releasing factor (CRF) receptors were identified in rat forebrain by autoradiography with an iodine-125-labeled analog of ovine CRF substituted with norleucine and tyrosine at amino acid residues 21 and 32, respectively. High-affinity receptors for CRF were found in discrete areas of rat forebrain, including laminae I and IV of the neocortex, the external layer of the medium eminence, the lateral nucleus of the amygdala, and the striatum. These results are consistent with earlier findings on the immunohistochemical distribution of CRF and suggest that endogenous CRF has a physiological role in regulating activity of the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De Souza, E B -- Perrin, M H -- Insel, T R -- Rivier, J -- Vale, W W -- Kuhar, M J -- AM26741/AM/NIADDK NIH HHS/ -- MH00053/MH/NIMH NIH HHS/ -- MH25951/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Jun 29;224(4656):1449-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328656" target="_blank"〉PubMed〈/a〉
Keywords:
Amygdala/physiology
;
Animals
;
Autoradiography
;
Brain/*physiology
;
Median Eminence/physiology
;
Rats
;
Receptors, Cell Surface/*physiology
;
Receptors, Corticotropin-Releasing Hormone
;
Visual Cortex/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink