Publication Date:
1994-01-07
Description:
Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular functions. TGF-beta signals through a heteromeric complex of the type I and type II TGF-beta receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-beta type I receptor on the basis of its ability to restore a TGF-beta-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bassing, C H -- Yingling, J M -- Howe, D J -- Wang, T -- He, W W -- Gustafson, M L -- Shah, P -- Donahoe, P K -- Wang, X F -- DK45746/DK/NIDDK NIH HHS/ -- NICHD T32HD07396/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1994 Jan 7;263(5143):87-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8272871" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Line
;
*Gene Expression Regulation
;
Genes, Reporter
;
Mutagenesis, Site-Directed
;
Protein-Serine-Threonine Kinases/metabolism
;
Rats
;
Rats, Sprague-Dawley
;
Receptors, Transforming Growth Factor beta/*metabolism
;
*Signal Transduction
;
Transfection
;
Transforming Growth Factor beta/*metabolism/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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