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  • 1
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    Observations constraining near-source ground motion estimated from locally recorded seismograms (1991)
    In:  J. Geophys. Res., New York, August, vol. 96, no. 3-4, pp. 16495-16508, pp. 1610, (ISSN: 1340-4202)
    Details
    Publication Date: 1991
    Keywords: Seismology ; JGR
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    BIBLIOGRAPHY SEISMOLOGY
  • 2
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    Attenuation of multiple ScS in various parts of the world (1988)
    In:  Geophys. J., Warszawa, Conseil de l'Europe, vol. 92, no. 5, pp. 303-314, pp. 1366, (ISBN: 0-12-018847-3)
    Details
    Publication Date: 1988
    Keywords: Seismology ; Attenuation ; Q-anomalies ; Quality factor
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    BIBLIOGRAPHY SEISMOLOGY
  • 3
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    Implications for continental structure and evolution from seismic anisotropy (1988)
    In:  Nature, Dordrecht, National Academy of Sciences of the USA, vol. 335, no. 5-6, pp. 34-39, pp. TC5003, (ISSN: 1340-4202)
    Details
    Publication Date: 1988
    Keywords: CRUST ; Anisotropy ; Seismology ; Geol. aspects
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    BIBLIOGRAPHY SEISMOLOGY
  • 4
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    Shear-wave splitting and mantle deformation (1991)
    In:  J. Geophys. Res., Dordrecht, National Academy of Sciences of the USA, vol. 96, no. 5-6, pp. 16429-16454, pp. TC5003, (ISSN: 1340-4202)
    Details
    Publication Date: 1991
    Keywords: AnisotropyS ; earth mantle ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; JGR
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    BIBLIOGRAPHY SEISMOLOGY
  • 5
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    A comparison of the spectral characteristics of nuclear explosions detonated below and above the water table (1989)
    Geophysics Laboratory
    In:  Technical Report, Leipzig, Geophysics Laboratory, vol. 10, no. GL-TR-89-0151, pp. 223-232, (ISBN 3-933346-037)
    Details
    Publication Date: 1989
    Keywords: Nuclear explosion ; Spectrum
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    BIBLIOGRAPHY SEISMOLOGY
  • 6
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    Requirement of CRTC1 coactivator for hepatitis B virus transcription (2014)
    Oxford University Press
    Details
    Publication Date: 2014-11-12
    Description: Transcription of hepatitis B virus (HBV) from the covalently closed circular DNA (cccDNA) template is essential for its replication. Suppressing the level and transcriptional activity of cccDNA might have anti-HBV effect. Although cellular transcription factors, such as CREB, which mediate HBV transcription, have been well described, transcriptional coactivators that facilitate this process are incompletely understood. In this study we showed that CREB-regulated transcriptional coactivator 1 (CRTC1) is required for HBV transcription and replication. The steady-state levels of CRTC1 protein were elevated in HBV-positive hepatoma cells and liver tissues. Ectopic expression of CRTC1 or its homolog CRTC2 or CRTC3 in hepatoma cells stimulated the activity of the preS2/S promoter of HBV, whereas overexpression of a dominant inactive form of CRTC1 inhibited HBV transcription. CRTC1 interacts with CREB and they are mutually required for the recruitment to the preS2/S promoter on cccDNA and for the activation of HBV transcription. Accumulation of pregenomic RNA (pgRNA) and cccDNA was observed when CRTC1 or its homologs were overexpressed, whereas the levels of pgRNA, cccDNA and secreted HBsAg were diminished when CRTC1 was compromised. In addition, HBV transactivator protein HBx stabilized CRTC1 and promoted its activity on HBV transcription. Our work reveals an essential role of CRTC1 coactivator in facilitating and supporting HBV transcription and replication.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 7
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    Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-10-23
    Description: Nonpeptide agonists of each of the five somatostatin receptors were identified in combinatorial libraries constructed on the basis of molecular modeling of known peptide agonists. In vitro experiments using these selective compounds demonstrated the role of the somatostatin subtype-2 receptor in inhibition of glucagon release from mouse pancreatic alpha cells and the somatostatin subtype-5 receptor as a mediator of insulin secretion from pancreatic beta cells. Both receptors regulated growth hormone release from the rat anterior pituitary gland. The availability of high-affinity, subtype-selective agonists for each of the somatostatin receptors provides a direct approach to defining their physiological functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rohrer, S P -- Birzin, E T -- Mosley, R T -- Berk, S C -- Hutchins, S M -- Shen, D M -- Xiong, Y -- Hayes, E C -- Parmar, R M -- Foor, F -- Mitra, S W -- Degrado, S J -- Shu, M -- Klopp, J M -- Cai, S J -- Blake, A -- Chan, W W -- Pasternak, A -- Yang, L -- Patchett, A A -- Smith, R G -- Chapman, K T -- Schaeffer, J M -- New York, N.Y. -- Science. 1998 Oct 23;282(5389):737-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biochemistry and Physiology, Merck Research Laboratories, Post Office Box 2000, Rahway, NJ 07065, USA. susanvrohrer@merck.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9784130" target="_blank"〉PubMed〈/a〉
    Keywords: Amides/metabolism/*pharmacology ; Amino Acid Sequence ; Animals ; Cell Line ; Cells, Cultured ; Cricetinae ; Drug Design ; Glucagon/secretion ; Growth Hormone/secretion ; Insulin/secretion ; Islets of Langerhans/drug effects/secretion ; Ligands ; Membrane Proteins ; Mice ; Models, Chemical ; Molecular Sequence Data ; Pituitary Gland, Anterior/drug effects/metabolism ; Rats ; Receptors, Somatostatin/*agonists/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    A nonpeptidyl growth hormone secretagogue (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-06-11
    Description: A nonpeptidyl secretagogue for growth hormone of the structure 3-amino-3-methyl-N-(2,3,4,5-tetrahydro-2-oxo-1-([2'-(1H-tetrazol-5 -yl) (1,1'-biphenyl)-4-yl]methyl)-1H-1-benzazepin-3(R)-yl)-butanamid e (L-692,429) has been identified. L-692,429 synergizes with the natural growth hormone secretagogue growth hormone-releasing hormone and acts through an alternative signal transduction pathway. The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6). L-692,429 is an example of a nonpeptidyl specific secretagogue for growth hormone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R G -- Cheng, K -- Schoen, W R -- Pong, S S -- Hickey, G -- Jacks, T -- Butler, B -- Chan, W W -- Chaung, L Y -- Judith, F -- New York, N.Y. -- Science. 1993 Jun 11;260(5114):1640-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Basic Animal Science Research, Merck Research Laboratories, Rahway, NJ 07065.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8503009" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Benzazepines/*pharmacology ; Cells, Cultured ; Dogs ; Growth Hormone/*drug effects/secretion ; Male ; Membrane Potentials/drug effects ; Molecular Sequence Data ; Oligopeptides/chemistry/pharmacology ; Pituitary Gland, Anterior/drug effects/secretion ; Rats ; Second Messenger Systems/drug effects ; Stereoisomerism ; Structure-Activity Relationship ; Tetrazoles/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Characteristics of Earthquakes in the Heerland Seismic Zone of Eastern Spitsbergen (1978)
    Alfred Wegener Institute for Polar and Marine Research & German Society of Polar Research
    In:  EPIC3Polarforschung, Bremerhaven, Alfred Wegener Institute for Polar and Marine Research & German Society of Polar Research, 48(1/2), pp. 31-40, ISSN: 0032-2490
    Details
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: "Polarforschung" , peerRev
    Format: application/pdf
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    PAPER (OA)
  • 10
    Electronic Resource
    Electronic Resource
    Seismicity and present-day tectonics of the Svalbard region (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 102 (1990), S. 0 
    Details
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Data collected by temporary seismic networks and individual stations over a 7-yr period in the Svalbard Archipelago are integrated and used to study the seismicity and present-day tectonics of the archipelago and surrounding regions. Most of the continental seismic activity occurs in three concentrated zones, one in Heer Land near the eastern coast of the island of Spitsbergen and two, in close proximity to one another, on the island of Nordaustlandet. All three zones are in regions which have been devoid of major orogenic activity since the late Devonian. the Heer Land zone and at least one of the zones in Nordaustlandet define active faulting which has not been identified by surface mapping. the other zone in Nordaustlandet occurs in the region of a mapped system of faults, all branches of which are relatively minor. A number of smaller concentrations and individual earthquakes occur throughout much of the archipelago and surrounding continental shelves. Seismicity is currently low in the region of Tertiary orogenic activity in western Spitsbergen. A roughly linear pattern of minor activity in southern Spitsbergen occurs west of the Heer Land zone and extends at least 50 km southward. the major N-S faults in Spitsbergen which are thought to have accomodated large displacements in Devonian time are currently inactive, except perhaps at the southern termini of the Billefjorden and Lomfjorden fault zones, where they approach the Heer land seismic zone. Earthquakes located near the western continental margin of Spitsbergen may occur on segments of rifting and shearing which reflect the opening of the Greenland Sea during the Tertiary. the limited extent of the currently active zones of activity, their spatial stability over several years, and the lack of activity on the major faults of Svalbard argue against the existence of plate boundaries, along which motion is currently occurring, in the Svalbard region.All fault-plane solutions on Svalbard are consistent with a stress field characterized by E-W compression, whereas previously published fault-plane solutions for the ridge system west of Svalbard indicate E-W extension. the magnitude of the compressive stress increases from small values near the ridge system to values sufficiently large to dominate the regional seismicity of Svalbard over distances of 200–300 km.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-246X.1990.tb00536.x
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    Paper (German National Licenses)
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