Publication Date:
1983-07-08
Description:
Two triglyceride lipases, lipoprotein lipase and hepatic triglyceride lipase, participate in the metabolism of plasma lipoproteins. A single recessive mutation, cld, on mouse chromosome 17 causes an apparent deficiency of both lipoprotein lipase and hepatic triglyceride lipase activities. Mice homozygous for this defect develop lethal hyperchylomicronemia within 2 days postpartum as a consequence of nursing. Plasma triglyceride values in affected mice often reach 20,000 milligrams per deciliter (100 times higher than that in normal littermates), and total lipase activity in plasma or tissues is 5 to 20 percent of that in controls.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paterniti, J R Jr -- Brown, W V -- Ginsberg, H N -- Artzt, K -- CA 21651/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):167-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857276" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cholesterol/blood
;
Chromosomes
;
Lipase/*deficiency/genetics
;
Lipoprotein Lipase/*deficiency/genetics
;
Lipoproteins/metabolism
;
Mice
;
*Mutation
;
Triglycerides/blood
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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