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  • 1
    Publication Date: 2011-10-18
    Description: SUMMARY The sequence of seismicity in the Dasht-e-Bayaz and Zirkuh region of northeastern Iran, which includes 11 destructive earthquakes within a period of only 30 years, forms one of the most outstanding examples of clustered large and intermediate-magnitude seismic activity in the world. We perform a multiple-event relocation analysis, with procedures to remove systematic location bias, of 169 earthquakes, most of which occurred in the period 1968–2008, to better image the distribution of seismicity within this highly active part of Iran. The geographic locations of the clustered earthquakes were calibrated by the inclusion of phase arrivals from seismic stations at short epicentral distances, and also by matching the relative locations of the three largest events in the study to their mapped surface ruptures. The two independent calibration methods provide similar results that increase our confidence in the accuracy of the distribution of relocated epicentres. These calibrated epicentres, combined with the mapping of faults from high-resolution satellite imagery, and from an InSAR-derived constraint on fault location in one case, allow us to associate individual events with specific faults, and even with specific segments of faults, to better understand the nature of the active tectonics in this region during the past four decades. Several previous assumptions about the seismicity in this region are confirmed: (1) that the 1968 August 30 M w 7.1 Dasht-e-Bayaz earthquake nucleated at a prominent segment boundary and left-step in the fault trace, (2) that the 1968 September 11 M w 5.6 aftershock occurred on the Dasht-e-Bayaz fault at the eastern end of the 1968 rupture and (3) that the 1976 November 7 M w 6.0 Qayen earthquake probably occurred on the E–W left-lateral Avash Fault. We show, in addition, that several significant events, including the 1968 September 1 and 4 ( M w 6.3 and 5.5) Ferdows earthquakes, the 1979 January 16 ( M w 6.5) and 1997 June 25 ( M w 5.9) Boznabad events and the 1979 December 7 ( M w 5.9) Kalat-e-Shur earthquake are likely to have ruptured previously unknown faults. Our improved description of the faulting involved in the 1968–1997 earthquake sequence highlights the importance of rupturing of conjugate left- and right-lateral faults in closely spaced events, or potentially even within a single earthquake, as was likely the case at the eastern end of the 1979 November 27 ( M w 7.1) Khuli-Buniabad main shock. The high level of clustered seismic activity probably results from the simultaneous activity on left- and right-lateral faults, an inherently unstable arrangement that must evolve rapidly. The combination of high-resolution satellite imagery and calibrated earthquake locations is a useful tool for investigating active tectonics, even in the absence of detailed field observations.
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 2
    Publication Date: 2015-10-28
    Description: Epigenetic silencing including histone modifications and DNA methylation is an important tumorigenic mechanism. However, its role in cancer immunopathology and immunotherapy is poorly understood. Using human ovarian cancers as our model, here we show that enhancer of zeste homologue 2 (EZH2)-mediated histone H3 lysine 27 trimethylation (H3K27me3) and DNA methyltransferase 1 (DNMT1)-mediated DNA methylation repress the tumour production of T helper 1 (TH1)-type chemokines CXCL9 and CXCL10, and subsequently determine effector T-cell trafficking to the tumour microenvironment. Treatment with epigenetic modulators removes the repression and increases effector T-cell tumour infiltration, slows down tumour progression, and improves the therapeutic efficacy of programmed death-ligand 1 (PD-L1; also known as B7-H1) checkpoint blockade and adoptive T-cell transfusion in tumour-bearing mice. Moreover, tumour EZH2 and DNMT1 are negatively associated with tumour-infiltrating CD8(+) T cells and patient outcome. Thus, epigenetic silencing of TH1-type chemokines is a novel immune-evasion mechanism of tumours. Selective epigenetic reprogramming alters the T-cell landscape in cancer and may enhance the clinical efficacy of cancer therapy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779053/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779053/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peng, Dongjun -- Kryczek, Ilona -- Nagarsheth, Nisha -- Zhao, Lili -- Wei, Shuang -- Wang, Weimin -- Sun, Yuqing -- Zhao, Ende -- Vatan, Linda -- Szeliga, Wojciech -- Kotarski, Jan -- Tarkowski, Rafal -- Dou, Yali -- Cho, Kathleen -- Hensley-Alford, Sharon -- Munkarah, Adnan -- Liu, Rebecca -- Zou, Weiping -- 5P30CA46592/CA/NCI NIH HHS/ -- CA099985/CA/NCI NIH HHS/ -- CA123088/CA/NCI NIH HHS/ -- CA152470/CA/NCI NIH HHS/ -- CA156685/CA/NCI NIH HHS/ -- CA171306/CA/NCI NIH HHS/ -- CA190176/CA/NCI NIH HHS/ -- CA193136/CA/NCI NIH HHS/ -- R01 CA099985/CA/NCI NIH HHS/ -- R01 CA123088/CA/NCI NIH HHS/ -- R01 CA152470/CA/NCI NIH HHS/ -- R01 CA156685/CA/NCI NIH HHS/ -- R01 CA171306/CA/NCI NIH HHS/ -- R01 CA190176/CA/NCI NIH HHS/ -- R01 CA193136/CA/NCI NIH HHS/ -- England -- Nature. 2015 Nov 12;527(7577):249-53. doi: 10.1038/nature15520. Epub 2015 Oct 26.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA. ; Graduate Program in Immunology, University of Michigan, Ann Arbor, Michigan 48109, USA. ; Department of Biostatistics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA. ; Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA. ; The First Department of Gynecologic Oncology and Gynecology, Medical University in Lublin, Lublin 20-081, Poland. ; The University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA. ; Department of Women's Health Services, Henry Ford Health System, Detroit, Michigan 48202, USA. ; Department of Obstetrics and Gynecology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA. ; Graduate Program in Tumor Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26503055" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD274/metabolism ; CD8-Positive T-Lymphocytes/cytology/immunology ; Chemokine CXCL10/biosynthesis/genetics/immunology ; Chemokine CXCL9/biosynthesis/genetics/immunology ; Chemokines/biosynthesis/*genetics/immunology ; DNA (Cytosine-5-)-Methyltransferase/antagonists & inhibitors/metabolism ; DNA Methylation/drug effects ; *Epigenesis, Genetic/drug effects ; Female ; *Gene Silencing ; Histones/chemistry/metabolism ; Humans ; *Immunotherapy/methods ; Lymphocytes, Tumor-Infiltrating/immunology ; Lysine/metabolism ; Mice ; Ovarian Neoplasms/enzymology/*immunology/pathology/*therapy ; Polycomb Repressive Complex 2/antagonists & inhibitors/metabolism ; Prognosis ; Th1 Cells/immunology/*metabolism ; Tumor Cells, Cultured ; Tumor Escape/immunology ; Xenograft Model Antitumor Assays
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2015-08-08
    Description: Detailed geodetic imaging of earthquake ruptures enhances our understanding of earthquake physics and associated ground shaking. The 25 April 2015 moment magnitude 7.8 earthquake in Gorkha, Nepal was the first large continental megathrust rupture to have occurred beneath a high-rate (5-hertz) Global Positioning System (GPS) network. We used GPS and interferometric synthetic aperture radar data to model the earthquake rupture as a slip pulse ~20 kilometers in width, ~6 seconds in duration, and with a peak sliding velocity of 1.1 meters per second, which propagated toward the Kathmandu basin at ~3.3 kilometers per second over ~140 kilometers. The smooth slip onset, indicating a large (~5-meter) slip-weakening distance, caused moderate ground shaking at high frequencies (〉1 hertz; peak ground acceleration, ~16% of Earth's gravity) and minimized damage to vernacular dwellings. Whole-basin resonance at a period of 4 to 5 seconds caused the collapse of tall structures, including cultural artifacts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galetzka, J -- Melgar, D -- Genrich, J F -- Geng, J -- Owen, S -- Lindsey, E O -- Xu, X -- Bock, Y -- Avouac, J-P -- Adhikari, L B -- Upreti, B N -- Pratt-Sitaula, B -- Bhattarai, T N -- Sitaula, B P -- Moore, A -- Hudnut, K W -- Szeliga, W -- Normandeau, J -- Fend, M -- Flouzat, M -- Bollinger, L -- Shrestha, P -- Koirala, B -- Gautam, U -- Bhatterai, M -- Gupta, R -- Kandel, T -- Timsina, C -- Sapkota, S N -- Rajaure, S -- Maharjan, N -- New York, N.Y. -- Science. 2015 Sep 4;349(6252):1091-5. doi: 10.1126/science.aac6383. Epub 2015 Aug 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geology and Planetary Sciences, California Institute of Technology (Caltech), Pasadena, CA 91125, USA. ; BerkeleySeismological Laboratory, University of California (UC)-Berkeley, Berkeley, CA 94720, USA. ; Cecil H. and Ida M. Green Institute of Geophysics and Planetary Physics, Scripps Institution of Oceanography, UC-San Diego, La Jolla, CA 92037, USA. ; Jet Propulsion Laboratory (JPL), Caltech, Pasadena, CA 91109, USA. ; Department of Earth Sciences, University of Cambridge, Cambridge CB2 3EQ, UK. Department of Geology and Planetary Sciences, California Institute of Technology (Caltech), Pasadena, CA 91125, USA. ; Department of Mines and Geology, Lainchour, Kathmandu, Nepal. ; Nepal Academy of Science and Technology, Khumaltar, Lalitpur, Nepal. ; Department of Geological Sciences, Central Washington University (CWU), Ellensberg, WA 98926, USA. ; Tri-Chandra Campus, Tribhuvan University, Ghantaghar, Kathmandu, Nepal. ; U.S. Geological Survey (USGS), Pasadena, CA 91106, USA. ; Pacific Northwest Geodetic Array and Department of Geological Sciences, CWU, Ellensberg, WA 98926, USA. ; UNAVCO, Boulder, CO 80301, USA. ; Departement Analyse et Sureveillance de l'Environnement (DASE), Commissariat a l'Energie Atomique (CEA), 91297 Bruyeres-le-Chatel, Arpajon, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26249228" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2014-07-23
    Description: GPS data reveal that the Brahmaputra Valley has broken from the Indian plate and rotates clockwise relative to India about a point a few hundred km west of the Shillong plateau The GPS velocity vectors define two distinct blocks separated by the Kopili fault upon which 2–3 mm/yr of dextral slip is observed: the Shillong block between longitudes 89-93°E rotating clockwise at 1.15 deg/My, and the Assam block from 93.5°E-97°E rotating at ≈ 1.13 deg/My. These two blocks are more than 120 km wide in a north–south sense, but they extend locally a similar distance beneath the Himalaya and Tibet. A result of these rotations is that convergence across the Himalaya east of Sikkim decreases in velocity eastwards from 18 to ≈ 12 mm/yr, and convergence between the Shillong plateau and Bangladesh across the Dauki fault increases from 3 mm/yr in the west to 〉8 mm/yr in the east. This fast convergence rate is inconsistent with inferred geological uplift rates on the plateau (if a 45°N dip is assumed for the Dauki fault) unless clockwise rotation of the Shillong block has increased substantially in the past 4–8 Myr. Such acceleration is consistent with reported recent slowing in the convergence rate across the Bhutan Himalaya. The current slip potential near Bhutan, based on present-day convergence rates and assuming no great earthquake since 1713 AD, is now ~5.4 m, similar to slip reported from alluvial terraces offsets across the Main Himalayan Thrust and sufficient to sustain a Mw ≥ 8.0 earthquake in this area.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    FEBS Letters 72 (1976), S. 327-330 
    ISSN: 0014-5793
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2016-02-10
    Description: The Makran subduction zone is one of the last convergent margins to be investigated using space-based geodesy. While there is a lack of historical and modern instrumentation in the region, a sparse sampling of continuous and campaign measurements over the past decade has allowed us to make the first estimates of convergence rates. We combine GPS measurements from 20 stations located in Iran, Pakistan and Oman along with hypocentral locations from the International Seismological Centre to create a preliminary 3-D estimate of the geometry of the megathrust, along with a preliminary fault-coupling model for the Makran subduction zone. Using a convergence rate which is strongly constrained by measurements from the incoming Arabia plate along with the backslip method of Savage, we find the Makran subduction zone appears to be locked to a depth of at least 38 km and accumulating strain.We also find evidence for a segmentation of plate coupling, with a 300 km long section of reduced plate coupling. The range of acceptable locking depths from our modelling and the 900 km along-strike length for the megathrust, makes the Makran subduction zone capable of earthquakes up to M w  = 8.8. In addition, we find evidence for slow-slip-like transient deformation events on two GPS stations. These observations are suggestive of transient deformation events observed in Cascadia, Japan and elsewhere.
    Keywords: Geodynamics and Tectonics
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 7
    Publication Date: 2018-02-01
    Print ISSN: 2169-9275
    Electronic ISSN: 2169-9291
    Topics: Geosciences , Physics
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  • 8
    Publication Date: 1976-12-31
    Print ISSN: 0014-5793
    Electronic ISSN: 1873-3468
    Topics: Biology , Chemistry and Pharmacology
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  • 9
    Publication Date: 2008-04-08
    Print ISSN: 0148-0227
    Electronic ISSN: 2156-2202
    Topics: Geosciences
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  • 10
    Publication Date: 2016-02-07
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
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