Publication Date:
1979-12-14
Description:
In cats under halothane or methoxyflurane, iontophoretic applications of choline are only eight times weaker than applications of acetylcholine in evoking firing of neurons in the sensorimotor region of the cerebral cortex. The action of choline is suppressed by atropine but not by two agents that block choline uptake (hemicholinium-3 and triethylcholine), and is not potentiated by an anticholinesterase (physostigmine). Choline therefore appears to excite cortical neurons by a direct action, which may be a significant component of its beneficial therapeutic effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krnjevic, K -- Reinhardt, W -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1321-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515735" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylcholine/pharmacology
;
Action Potentials/drug effects
;
Animals
;
Cats
;
Cerebral Cortex/*drug effects
;
Choline/*pharmacology
;
Drug Synergism
;
Evoked Potentials
;
Glutamates/pharmacology
;
Hemicholinium 3/pharmacology
;
Motor Cortex/physiology
;
Physostigmine/pharmacology
;
Receptors, Muscarinic/drug effects
;
Stimulation, Chemical
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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