Publication Date:
2000-09-29
Description:
Direction-selective ganglion cells (DSGCs) in the retina respond strongly when stimulated by image motion in a preferred direction but are only weakly excited by image motion in the opposite null direction. Such coding represents an early manifestation of complex information processing in the visual system, but the cellular locus and the synaptic mechanisms have yet to be elucidated. We recorded the synaptic activity of DSGCs using strategies to observe the asymmetric inhibitory inputs that underlie the generation of direction selectivity. The critical nonlinear interactions between the excitatory and inhibitory inputs took place postsynaptically within the dendrites of the DSGCs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taylor, W R -- He, S -- Levick, W R -- Vaney, D I -- New York, N.Y. -- Science. 2000 Sep 29;289(5488):2347-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉John Curtin School of Medical Research, Centre for Visual Sciences, Department of Psychology, Australian National University, Canberra, ACT 2601, Australia. Rowland.Taylor@anu.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11009420" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Chloride Channels/metabolism
;
Chlorides/metabolism
;
Culture Techniques
;
Dendrites/*physiology
;
Excitatory Postsynaptic Potentials
;
Interneurons/physiology
;
Motion Perception/*physiology
;
Neural Inhibition
;
Patch-Clamp Techniques
;
Rabbits
;
Retinal Ganglion Cells/*physiology
;
Sodium Channels/metabolism
;
Synapses/physiology
;
Synaptic Transmission
;
gamma-Aminobutyric Acid/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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