Publication Date:
1983-05-27
Description:
Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-beta-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van Kammen, D P -- Mann, L S -- Sternberg, D E -- Scheinin, M -- Ninan, P T -- Marder, S R -- van Kammen, W B -- Rieder, R O -- Linnoila, M -- New York, N.Y. -- Science. 1983 May 27;220(4600):974-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6133351" target="_blank"〉PubMed〈/a〉
Keywords:
Adolescent
;
Adult
;
Aged
;
Animals
;
Antipsychotic Agents/adverse effects
;
Atrophy
;
Brain/metabolism/*pathology
;
Dopamine/metabolism
;
Dopamine beta-Hydroxylase/*cerebrospinal fluid
;
Homovanillic Acid/*cerebrospinal fluid
;
Humans
;
Middle Aged
;
Phenylacetates/*cerebrospinal fluid
;
Rats
;
Schizophrenia/*cerebrospinal fluid
;
Tomography, X-Ray Computed
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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