ISSN:
1573-0778
Keywords:
CG suppression
;
DNA methylation
;
gene expression
;
MHC
;
mutation hot spots
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Abstract DNA methylation of human class II genes of the Major Histocompatibility Complex (MHC) was correlated with gene expression and methyl-related CG → TG and CG → CA changes. It was found that cytosine methylation of the CG dinucleotides of MHC class II genes should be involved in generating a fraction of nucleotide polymorphism, rather than in controlling transcription.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00146813
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