ISSN:
1075-4261
Keywords:
cyclodextrins
;
diclofenac
;
inclusion complexes
;
chemical shifts
;
1H-NMR spectroscopy
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Physics
Notes:
The interaction between diclofenac (sodium salt of 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid) and β-cyclodextrin in aqueous solution has been investigated by 1H-NMR spectroscopic technique. The technique is based on the shielding of the β-cyclodextrin and drug protons. The spectra showed upfield shifts of the β-cyclodextrin protons in the presence of diclofenac, and the diclofenac protons also shifted upfield in the presence of β-cyclodextrin. The changes in chemical shifts of suitable guest-host protons are consistent with the formation of an inclusion complex diclofenac/β-cyclodextrin. © 1997 John Wiley & Sons, Inc. Biospect 3:233-239, 1997
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
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