ISSN:
1432-0878
Keywords:
Pancreas, endocrine
;
Stomach
;
Intestine
;
Immunohistochemistry
;
Thyrotropin-releasing hormone (TRH)
;
Somatostatin
;
Avian pancreatic polypeptide
;
Insulin
;
Gastrin
;
Rat
;
Guinea pig
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary By use of the indirect immunofluorescence technique, the cellular localization of thyrotropin-releasing hormone (TRH) was studied in the gastrointestinal tract of rats and guinea pigs of different ages. TRH-like immunoreactivity (LI) was observed in many pancreatic islet cells of young rats and guinea pigs but only in single cells of 6-month-old rats. In aged guinea pigs, a reduction in the number of TRH-positive cells was evident; however, numerous strongly fluorescent cells were still present. In the guinea pig, TRH-LI was in addition observed in gastrin cells in the stomach. TRH-positive nerve fibers occurred in the myenteric plexus of the oesophagus, stomach and intestine of the rat, and in the muscle layers of the guinea pig. These results suggest a functional role of TRH both as hormone and neuroactive compound in various portions and sites of the gastro-intestinal tract of the rat and guinea pig
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00222291
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