ISSN:
1420-9071
Keywords:
Key words. Pituitary development; Pit-1; GHF-1; transcription factors; gene expression.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract. Anterior pituitary differentiation is a well-established paradigm in mammalian organogenesis. PIT1/GHF1, a homoeotic gene, plays a key role in terminal pituitary differentiation. Recently, a new set of transcription factors involved in early pituitary differentiation have been identified Lhx-3, Lhx-4, P-OTX and Prop1. A pituitary-specific transcriptional cascade regulating a developmental programme leads to the determination of the mature cell types.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s000180050234
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