ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Betablocker drugs
;
Lipophilicity
;
Capacity factors
;
Distribution coefficients
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The reverse-phase, high-pressure liquid chromatographic capacity factors (k') of a series of 18 betablocking agents were determined in order to establish correlations with their distribution coefficient values (D), obtained from four bibliographic sources. Under the three pH conditions studied (3.5, 6.2 and 7.5) statistically significant linear correlations (p〈 0.002) between log k' and log D values were obtained for the four series studied. In this series it is concluded that the k' factor is a useful and reliable relative lipophilicity parameter.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02257296
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