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    Chromosome size-dependent control of meiotic recombination (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-04-10
    Description: Smaller chromosomes have higher rates of meiotic reciprocal recombination (centimorgans per kilobase pair) than larger chromosomes. This report demonstrates that decreasing the size of Saccharomyces cerevisiae chromosomal DNA molecules increases rates of meiotic recombination and increasing chromosome size decreases recombination rates. These results indicate that chromosome size directly affects meiotic reciprocal recombination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaback, D B -- Guacci, V -- Barber, D -- Mahon, J W -- New York, N.Y. -- Science. 1992 Apr 10;256(5054):228-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Molecular Genetics, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark 07103.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1566070" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Mapping ; Chromosomes, Fungal/*physiology ; DNA, Fungal/genetics ; Gene Conversion ; Genes, Fungal ; Homozygote ; Karyotyping ; Meiosis/*genetics ; *Recombination, Genetic ; Saccharomyces cerevisiae/cytology/*genetics ; Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    A molecular determinant for the establishment of sister chromatid cohesion (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-07-26
    Description: Chromosome segregation, transcriptional regulation, and repair of DNA double-strand breaks require the cohesin protein complex. Cohesin holds the replicated chromosomes (sister chromatids) together to mediate sister chromatid cohesion. The mechanism of how cohesion is established is unknown. We found that in budding yeast, the head domain of the Smc3p subunit of cohesin is acetylated by the Eco1p acetyltransferase at two evolutionarily conserved residues, promoting the chromatin-bound cohesin to tether sister chromatids. Smc3p acetylation is induced in S phase after the chromatin loading of cohesin and is suppressed in G(1) and G(2)/M. Smc3 head acetylation and its cell cycle regulation provide important insights into the biology and mechanism of cohesion establishment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Unal, Elcin -- Heidinger-Pauli, Jill M -- Kim, Woong -- Guacci, Vincent -- Onn, Itay -- Gygi, Steven P -- Koshland, Douglas E -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Jul 25;321(5888):566-9. doi: 10.1126/science.1157880.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Embryology, Carnegie Institution, 3520 San Martin Drive, Baltimore, MD 21218, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18653894" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Acetyltransferases/genetics/*metabolism ; Amino Acid Sequence ; Amino Acid Substitution ; Cell Cycle Proteins/chemistry/genetics/*metabolism ; Cell Division ; Chondroitin Sulfate Proteoglycans/chemistry/genetics/*metabolism ; Chromatids/*physiology ; Chromatin/metabolism ; Chromosomal Proteins, Non-Histone/chemistry/genetics/*metabolism ; Chromosomes, Fungal/*physiology ; G1 Phase ; G2 Phase ; Immunoprecipitation ; Lysine/metabolism ; Molecular Sequence Data ; Mutation ; Nuclear Proteins/genetics/*metabolism ; Protein Structure, Tertiary ; S Phase ; Saccharomyces cerevisiae/genetics/growth & development/*physiology ; Saccharomyces cerevisiae Proteins/chemistry/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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