ISSN:
1573-8353
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Protonation and methylation of 5-oxo-7,12-dihydro-5H-isoquino[2,3-a]quinazoline occur at the N(6) atom, while methylation of 5-oxo- and 6-methyl-5-oxo-6,6a,7,12-tetrahydro-5H-isoquino[2,3-a]quinazolines takes place at the N(13) atom; the degree of stereoselectivity varies depending on the presence of a substituent attached to N(13). Based on PMR spectral analysis utilizing the nuclear Overhauser effect, we have established the structure and studied the conformational behavior of the tosylate derivatives of cis-13-methyl-, trans-13-methyl-, and cis-6,13-dimethyl-5-oxo-6,6a,7-12-tetrahydro-5H-isoquino[2,3-a]quinazolinium ions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00474239
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