Publication Date:
2014-11-16
Description:
Article The COP9 signalosome (CSN) is a protein complex involved in protein degradation and tumorigenesis. Here the authors show that the CSN6 subunit antagonizes the deneddylation function of CSN5 towards ubiquitin ligase Cullin-1, resulting in Fbxw7 ubiquitin ligase degradation and thereby stabilization of the Fbxw7 target Myc. Nature Communications doi: 10.1038/ncomms6384 Authors: Jian Chen, Ji-Hyun Shin, Ruiying Zhao, Liem Phan, Hua Wang, Yuwen Xue, Sean M. Post, Hyun Ho Choi, Jiun-Sheng Chen, Edward Wang, Zhongguo Zhou, Chieh Tseng, Christopher Gully, Guermarie Velazquez-Torres, Enrique Fuentes-Mattei, Giselle Yeung, Yi Qiao, Ping-Chieh Chou, Chun-Hui Su, Yun-Chih Hsieh, Shih-Lan Hsu, Kazufumi Ohshiro, Tattym Shaikenov, Huamin Wang, Sai-Ching Jim Yeung, Mong-Hong Lee
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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