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Human recombinant interleukin-1 receptor antagonist blocks bone resorption induced by interleukin-1β but not interleukin-1α (1994)

Chole, R. A. ; Tinling, S. P. ; Faddis, B. T.

Springer

Calcified tissue international 55 (1994), S. 12-15

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ISSN: 1432-0827

Keywords: IL-1α ; IL-1β ; IL-1 receptor antagonist ; Bone ; Calcium ; Parathyroid hormone

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine , Physics

Notes: Abstract Both interleukin-1α (IL-1α) and interleukin-1β (IL-1β) are powerful stimulators of bone resorption in vivo and in vitro. Interleukin-1 receptor antagonist (IL-1ra) binds to many interleukin-1 receptors. It does not activate the receptor and effectively blocks the action of IL-1α and IL-1β. In this study, human recombinant IL-1ra, at 100-fold excess, was found to block bone resorption in cultured mouse calvaria due to IL-1β but not IL-1α. These observations may be explained by differential affinities of receptors for IL-1α, IL-1β and rhIL-1ra on target bone cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00310162

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