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  • 1
    Electronic Resource
    Electronic Resource
    Tales of old (1991)
    [s.l.] : Nature Publishing Group
    Nature 352 (1991), S. 767-768 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ONE of Aristotle's many claims to fame is as the great grandaddy of geronto-logical science. "It is not clear whether in animals or plants universally it is a single or diverse cause that makes some to be long-lived, others short-lived." Thus mused Aristotle some 23 centuries ago in his De ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/352767b0
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  • 2
    Electronic Resource
    Electronic Resource
    Human longevity at the cost of reproductive success (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 396 (1998), S. 743-746 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The disposable soma theory on the evolution of ageing states that longevity requires investments in somatic maintenance that reduce the resources available for reproduction,. Experiments in Drosophila melanogaster indicate that trade-offs of this kind exist in non-human species. We have ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/396743a0
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  • 3
    Electronic Resource
    Electronic Resource
    Why do we age? (2000)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 408 (2000), S. 233-238 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence. Such understanding also helps to clarify how the genome shapes the ageing process, thereby aiding the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35041682
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  • 4
    Electronic Resource
    Electronic Resource
    Ageing The old worm turns more slowly (2002)
    [s.l.] : Nature Publishing Group
    Nature 419 (2002), S. 794-795 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] When the nematode worm Caenorhabditis elegans was first considered as a model for the study of ageing some 20 years ago, few foresaw how valuable it would prove to be. The past decade, in particular, has seen an explosion of work on the genetics of lifespan in this species. Building on pioneering ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/419794a
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  • 5
    Electronic Resource
    Electronic Resource
    Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress (1982)
    Springer
    Human genetics 〈Berlin〉 60 (1982), S. 101-121 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cytogerontology, the science of cellular ageing, originated in 1881 with the prediction by August Weismann that the somatic cells of higher animals have limited division potential. Weismann's prediction was derived by considering the role of natural selection in regulating the duration of an organism's life. For various reasons, Weismann's ideas on ageing fell into neglect following his death in 1914, and cytogerontology has only reappeared as a major research area following the demonstration by Hayflick and Moorhead in the early 1960s that diploid human fibroblasts are restricted to a finite number of divisions in vitro. In this review we give a detailed account of Weismann's theory, and we reveal that his ideas were both more extensive in their scope and more pertinent to current research than is generally recognised. We also appraise the progress which has been made over the past hundred years in investigating the causes of ageing, with particular emphasis being given to (i) the evolution of ageing, and (ii) ageing at the cellular level. We critically assess the current state of knowledge in these areas and recommend a series of points as primary targets for future research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00569695
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  • 6
    Electronic Resource
    Electronic Resource
    Colonization and degradation of oxidized bituminous and lignite coals by fungi (1990)
    Springer
    Journal of industrial microbiology and biotechnology 6 (1990), S. 53-59 
    Details
    ISSN: 1476-5535
    Keywords: Bituminous coal ; Biosolubilization ; Penicillium sp. ; Surface colonization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary APenicillium sp. previously shown to grow on lignite coals degraded an air-oxidized bituminous coal (Illinois #6) to a material that was more than 80% soluble in 0.5 N NaOH. Scanning electron microscopy of the oxidized Illinois #6 revealed colonization of the surface by thePenicillium sp., production of conidia, and erosion of the coal surface. The average molecular weight (MW) of Illinois #6 degraded by the fungus and base-solubilized was approximately 1000 Da. The average MW for base-solubilized Illinois #6 that was not exposed to the fungus was 6000 Da, suggesting solubilizing mechanisms other than base catalysis. A spectrophotometric assay to quantify the microbial conversion of biosolubilized coal was developed. Standard curves were constructed based on the absorbance at 450 nm of different quantities of microbe-solubilized coal. An acid precipitation step was necessary to remove medium and/or microbial metabolites from solubilized coal to prevent overestimation of the extent of coal biosolubilization. Furthermore, the absorption spectra for different coal products varied, necessitating construction of standard curves for individual coals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01576177
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  • 7
    Electronic Resource
    Electronic Resource
    Microbial transformation of alkylpyridines in groundwater (1985)
    Springer
    Water, air & soil pollution 24 (1985), S. 443-454 
    Details
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The microbiological degradation of a mixture of alkylpyridines in groundwater maintained under aerobic and anaerobic conditions was examined. A marked difference was observed between the aerobic and anaerobic degradation rates. In the presence of a soil inoculum and under aerobic conditions, the residual alkylpyridine concentrations generally approached zero concentration within 10 to 31 days of incubation, whereas under anaerobic conditions the concentrations of residual alkylpyridines only decreased between 40 and 80% over a 33 day incubation period. Biodegradation rates under aerobic conditions were greatly affected by the specific ring substitution of structural isomers within a given weight class. A similar effect was not observed for anaerobic degradation rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282494
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  • 8
    Electronic Resource
    Electronic Resource
    Human senescence (1996)
    New York, NY : Wiley-Blackwell
    BioEssays 18 (1996), S. 1009-1016 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Human life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require integration of molecular, cellular, genetic and physiological approaches. This article reviews progress that has been made to date, particularly with regard to the genetic contribution to senescence and longevity, and assesses the scale of the task that remains.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950181211
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  • 9
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    The free-radical theory of ageing – older, wiser and still alive (2012)
    Wiley
    In: BioEssays
    Details
    Publication Date: 2012-05-30
    Description: The continuing viability of the free-radical theory of ageing has been questioned following apparently incompatible recent results. We show by modelling positional effects of the generation and primary targets of reactive oxygen species that many of the apparently negative results are likely to be misleading. We conclude that there is instead a need to look more closely at the mechanisms by which free radicals contribute to age-related dysfunction in living systems. There also needs to be deeper understanding of the dynamics of accumulation and removal of the various kinds of molecular damage, in particular mtDNA mutations. Finally, the expectation that free-radical damage on its own might cause ageing needs to be relinquished in favour of the recognition that the free-radical theory is just one of the multiple mechanisms driving the ageing process. The free-radical theory is more complex than commonly recognized. Spatial effects need to be considered; e.g. mitochondrial DNA, a main target of ROS, is attached to the inner mitochondrial membrane, where most radicals are produced. This influences the likely effectiveness of antioxidants (AOx) and of turnover processes to control cellular damage.
    Print ISSN: 0265-9247
    Electronic ISSN: 1521-1878
    Topics: Biology , Medicine
    Published by Wiley
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  • 10
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    Tips for youth (2003)
    Springer Nature
    Details
    Publication Date: 2003-06-01
    Print ISSN: 1465-7392
    Electronic ISSN: 1476-4679
    Topics: Biology , Medicine
    Published by Springer Nature
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