ISSN:
1573-4935
Keywords:
ciglitazone
;
thermogenesis
;
brown adipose tissue
;
GDP binding
;
mice
;
BRL 26830A
;
beta agonist
;
metabolic rate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Chronic dietary administration of the oral hypoglycaemic ciglitazone (3 g/day for 14–28 days) to lean, non-diabetic CD1 mice resulted in increased brown adipose tissue mitochondrial GDP binding and a marked increase in the thermic effect of the beta-adrenoceptor agonist BRL 26830A. However, ciglitazone was not itself thermogenic after an acute dose, nor did it raise resting metabolic rate during chronic dietary dosing.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01119774
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