Publication Date:
1981-09-11
Description:
Immunoglobulin G and Fab antibodies were isolated from the serum of vasectomized guinea pigs, and the effects of the antibodies on fertilization in vitro were investigated. These antibodies had profound inhibitory effects on (i) sperm-to-sperm adhesion, (ii) the acrosome reaction, (iii) sperm-zona binding, and (iv) sperm-ovum fusion. This finding may explain certain cases of infertility after vasovasostomy in men.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, T T Jr -- Tung, K S -- Yanagimachi, R -- HD-03402/HD/NICHD NIH HHS/ -- HD-05944-01/HD/NICHD NIH HHS/ -- HD-12247/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1981 Sep 11;213(4513):1267-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7268435" target="_blank"〉PubMed〈/a〉
Keywords:
Acrosome/physiology
;
Animals
;
*Autoantibodies
;
*Fertilization in Vitro
;
Guinea Pigs
;
Immunoglobulin Fab Fragments
;
Immunoglobulin G
;
Infertility, Male/*immunology
;
Male
;
Sperm Capacitation
;
Spermatozoa/*immunology
;
*Sterilization Reversal
;
*Vasectomy
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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