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  • 1
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    Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1 (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-11-09
    Description: Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, D H -- de Waal Malefyt, R -- Fiorentino, D F -- Dang, M N -- Vieira, P -- de Vries, J -- Spits, H -- Mosmann, T R -- Moore, K W -- New York, N.Y. -- Science. 1990 Nov 9;250(4982):830-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2173142" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; DNA, Viral/genetics ; Electrophoresis, Polyacrylamide Gel ; *Gene Expression Regulation, Viral ; Herpesvirus 4, Human/genetics/*immunology ; Humans ; Interleukin-10 ; Interleukins/*biosynthesis ; Killer Cells, Natural/immunology ; Mice ; Radioimmunoprecipitation Assay ; T-Lymphocytes/immunology ; Viral Proteins/genetics/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-06-08
    Description: Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moore, K W -- Vieira, P -- Fiorentino, D F -- Trounstine, M L -- Khan, T A -- Mosmann, T R -- New York, N.Y. -- Science. 1990 Jun 8;248(4960):1230-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2161559" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Cell Line ; Cloning, Molecular ; Codon/genetics ; *Genes, Viral ; Herpesvirus 4, Human/*genetics ; Interleukin-10 ; Interleukins/*genetics ; Mice ; Molecular Sequence Data ; Nucleic Acid Hybridization ; RNA, Messenger/genetics ; Restriction Mapping ; Sequence Homology, Nucleic Acid ; T-Lymphocytes, Helper-Inducer/immunology ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Cytokine patterns during the progression to AIDS (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-07-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mosmann, T R -- New York, N.Y. -- Science. 1994 Jul 8;265(5169):193-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, University of Alberta, Edmonton, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8023139" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*immunology/microbiology ; Cytokines/*biosynthesis ; HIV/physiology ; HIV Antibodies/biosynthesis ; HIV Infections/*immunology/microbiology ; Humans ; Interferon-gamma/biosynthesis ; Interleukins/biosynthesis ; Lymph Nodes/immunology/microbiology ; Lymphotoxin-alpha/biosynthesis ; T-Lymphocytes, Helper-Inducer/*immunology/microbiology ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Amphiregulin, a TH2 cytokine enhancing resistance to nematodes (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-12-16
    Description: Although type 2 immune responses contribute to allergy and asthma, these responses are essential for clearing intestinal helminth infestations by mechanisms that include increased epithelial shedding. We show that T helper 2 cells (T(H)2), but not other T cell subsets, express amphiregulin, a member of the epidermal growth factor (EGF) family. EGF receptor ligands directly induce epithelial cell proliferation, and lack of amphiregulin delayed expulsion of the nematode Trichuris muris. This newly recognized link between T(H)2 cells and epithelial proliferation should help in planning therapeutic interventions for helminth infections and other diseases that involve both cell proliferation and allergy, such as asthma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zaiss, Dietmar M -- Yang, Li -- Shah, Pranav R -- Kobie, James J -- Urban, Joseph F -- Mosmann, Tim R -- AI48604/AI/NIAID NIH HHS/ -- DFG/ZA280/PHS HHS/ -- New York, N.Y. -- Science. 2006 Dec 15;314(5806):1746.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉David H. Smith Center for Vaccine Biology and Immunology and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17170297" target="_blank"〉PubMed〈/a〉
    Keywords: Amphiregulin ; Animals ; Bone Marrow Cells/immunology/metabolism ; Cecum/pathology ; Cell Line ; Cell Proliferation ; Cytokines/biosynthesis/immunology ; EGF Family of Proteins ; Gene Expression Regulation ; Glycoproteins/biosynthesis/genetics/*physiology ; Immunity, Innate ; Intercellular Signaling Peptides and Proteins/biosynthesis/genetics/*physiology ; Intestinal Mucosa/pathology ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Polymerase Chain Reaction ; Th2 Cells/*immunology/metabolism ; Trichuriasis/*immunology/parasitology/pathology ; Trichuris/immunology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    Lymphokine Control of in Vivo Immunoglobulin Isotype Selection (1990)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 8 (1990), S. 303-333 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.iy.08.040190.001511
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  • 6
    Electronic Resource
    Electronic Resource
    TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties (1989)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 7 (1989), S. 145-173 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.iy.07.040189.001045
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  • 7
    Electronic Resource
    Electronic Resource
    Interleukin-10 (1993)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 11 (1993), S. 165-190 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.iy.11.040193.001121
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  • 8
    Electronic Resource
    Electronic Resource
    T Lymphocyte Subsets, Cytokines, and Effector Functions (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 664 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb39751.x
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  • 9
    Electronic Resource
    Electronic Resource
    A strong, preferential response of mice to polymorphic antigenic determinants of the chicken MHC, analyzed with mouse hybridoma (monoclonal) antibodies (1979)
    Springer
    Immunogenetics 9 (1979), S. 137-147 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract CBA/J mice were immunized with B2/B2 chicken RBC's (theB locus is the major histocompatibility complex (MHC) of the chicken). Spleen cells from these mice gave a much higher plaque-forming cell response when tested with RBC's bearing B2 alloantigens, than with RBC's bearing any other MHC alloantigens. Similarly, immunization with chicken RBC's of other genotypes also produced responses that were highest when tested on the genotype used for immunization. Spleen cells from mice immunized 3 days previously with B2/B2 RBC's were fused with mouse myeloma cells and hybrid clones which secreted anti-B2 antibodies were selected. These monoclonal antibodies could be divided into three groups: (1) those which react with all genotypes of RBC's (panreactive); (2) those which react with only certain genotypes of RBC's and detect “public” MHC antigens; and (3) those which react with only B2/B2 RBC's and detect “private” MHC antigens. Monoclonal antibodies which detect a private B2 alloantigen were shown to be excellent typing reagents, as all birds of an outbred population which possessed the B2 allele were easily detected using a simple one-step direct agglutination assay. No “false positives” were seen. The high and preferential response of the mouse to chicken MHC alloantigens suggested that mice might possess preexisting immunity to these antigens. In agreement with this hypothesis, normal mouse serum was found to have high titres of “natural” antibody against chicken MHC antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01570404
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  • 10
    Electronic Resource
    Electronic Resource
    Restricted expression of an MHC alloantigen in cells of the erythroid series: A specific marker for erythroid differentiation (1980)
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 13 (1980), S. 395-400 
    Details
    ISSN: 0091-7419
    Keywords: MHC ; erythropoiesis ; differentiation marker ; B-G locus ; monoclonal antibody ; Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: The spectrum of reactivity with various types of cells of a monoclonal antibody (CH-4) which detects a private MHC antigen of chickens was analysed. CH-4 agglutinates only RBCs that possess the B2 (MHC) haplotype. A new rosetteforming cell (RFC) assay was devised to detect individual cells (excluding RBCs) that possess the CH-4 specificity on their cell surfaces. RBCs that have CH-4 chemically coupled to their surfaces attach to, and form rosettes with, B2 antigen-bearing cells. Most non-RBC RFC were detected in active erythropoietic organs (adult bone marrow and embryonic spleen), and none were found in organs where erythropoiesis does not occur: adult thymus and bursa. Preincubation of bone marrow cells with CH-4 plus complement almost completely inhibits their capacity to form CFU-E without affecting their ability to form GM-CFU. In addition, CH-4 plus complement does not inhibit the capacity of B2/B2 lymphocytes to induce a graft-versus-host reaction under conditions where anti-B2 lymphocyte alloantisera are completely inhibitory. Our results strongly suggest that CH-4 monoclonal antibodies detect a private specificity on a gene product of the B-G locus whose expression is restricted to erythroid stem cells and erythrocytes.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jss.400130310
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