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  • 1
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    Oxysterols are agonist ligands of ROR{gamma}t [Immunology and Inflammation] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-08-20
    Description: The RAR-related orphan receptor gamma t (RORγt) is a nuclear receptor required for generating IL-17–producing CD4+ Th17 T cells, which are essential in host defense and may play key pathogenic roles in autoimmune diseases. Oxysterols elicit profound effects on immune and inflammatory responses as well as on cholesterol and lipid...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-05-09
    Description: Inheritance of each chromosome depends upon its centromere. A histone H3 variant, centromere protein A (CENP-A), is essential for epigenetically marking centromere location. We find that CENP-A is quantitatively retained at the centromere upon which it is initially assembled. CENP-C binds to CENP-A nucleosomes and is a prime candidate to stabilize centromeric chromatin. Using purified components, we find that CENP-C reshapes the octameric histone core of CENP-A nucleosomes, rigidifies both surface and internal nucleosome structure, and modulates terminal DNA to match the loose wrap that is found on native CENP-A nucleosomes at functional human centromeres. Thus, CENP-C affects nucleosome shape and dynamics in a manner analogous to allosteric regulation of enzymes. CENP-C depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610723/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610723/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Falk, Samantha J -- Guo, Lucie Y -- Sekulic, Nikolina -- Smoak, Evan M -- Mani, Tomoyasu -- Logsdon, Glennis A -- Gupta, Kushol -- Jansen, Lars E T -- Van Duyne, Gregory D -- Vinogradov, Sergei A -- Lampson, Michael A -- Black, Ben E -- CA186430/CA/NCI NIH HHS/ -- GM007229/GM/NIGMS NIH HHS/ -- GM008216/GM/NIGMS NIH HHS/ -- GM008275/GM/NIGMS NIH HHS/ -- GM082989/GM/NIGMS NIH HHS/ -- R01 GM082989/GM/NIGMS NIH HHS/ -- T32 GM008216/GM/NIGMS NIH HHS/ -- T32 GM008275/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2015 May 8;348(6235):699-703. doi: 10.1126/science.1259308.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Graduate Program in Cell and Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Graduate Program in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Graduate Program in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Instituto Gulbenkian de Ciencia, 2780-156 Oeiras, Portugal. ; Graduate Program in Cell and Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Graduate Program in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Graduate Program in Cell and Molecular Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Graduate Program in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. blackbe@mail.med.upenn.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25954010" target="_blank"〉PubMed〈/a〉
    Keywords: Autoantigens/chemistry/genetics/*metabolism ; Centromere/chemistry/*metabolism/ultrastructure ; Chromosomal Proteins, Non-Histone/chemistry/genetics/*metabolism ; DNA/chemistry/metabolism ; Epigenesis, Genetic ; Fluorescence Resonance Energy Transfer ; Gene Knockdown Techniques ; Humans ; Nucleosomes/chemistry/*metabolism/ultrastructure ; Protein Structure, Secondary
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Study into solar-still performance under sealed and unsealed conditions (2015)
    Oxford University Press
    Details
    Publication Date: 2015-11-07
    Description: Safe water is fundamental to life and sustainable development. Despite modern civilization pacing into the 21st century, global access to safe water is disparate and inadequate particularly in south Asia and Africa. The need of the hour is to promote appropriate technologies, such as desalination, which are economically viable and environmentally conducive. With increasing stress on renewable energy use, technologies based on effectively harnessing solar energy would prove sustainable. Solar-still is a desalination technology that effectively harnesses solar energy. Solar-stills generate safe water from either contaminated and/or brackish water. They are an enabling domestic technology that can suit de-centralized operation and maintenance. Their fundamental dependence on solar energy and relatively low yield has thus far impeded wide-spread adoption. The current article discusses the prospects of solar-stills as a safe-water technology. Subsequently, an innovative low internal-volume stepped solar-still has been commissioned and tested for its productivity under sealed and unsealed conditions. The results of the experimental investigation have been discussed in this article. The salient contribution in this article pertains to the performance of a stepped solar-still under sealed and unsealed conditions. Such an investigation has been found to be crucial, but hitherto unattended to.
    Keywords: Solar energy technologies
    Print ISSN: 1748-1317
    Electronic ISSN: 1748-1325
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Oxford University Press
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  • 4
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    The Gastroprotective Role of Acanthus ilicifolius – A Study to Unravel the Underlying Mechanism of Anti-Ulcer Activity (2012)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2012-01-01
    Print ISSN: 0036-8709
    Electronic ISSN: 2218-0532
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 5
    Electronic Resource
    Electronic Resource
    The physical characteristics of PPG/PMMA/LiCF"3SO"3 polymer electrolyte blends including morphology
    Amsterdam : Elsevier
    Solid State Ionics 60 (1993), S. 113-117 
    Details
    ISSN: 0167-2738
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-2738(93)90283-9
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Zone refining of sintered, microwave derived YBCO superconductors (1995)
    Springer
    Journal of materials science 30 (1995), S. 3238-3241 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Post-sintering treatments, such as zone melting under a thermal gradient, have been conducted on sintered YBCO tape cast films. YBCO precursor powder was derived through decomposition of a mixture of nitrates of cations in a microwave oven for ~ 4 min. The resulting powder was characterized and made into thin sheets by tape casting and then sintered at 945 °C for 5 h. The sintered tapes were subjected to repeated zone refining operations at the relatively high speed of ~ 30 mm h−1. A microstructure having uniformly orientated grains in thea-b plane throughout the bulk of the sample was obtained by three repeated zone refining operations. Details of precursor preparation, microwave processing and its advantages, zone refining conditions and microstructural features are presented in this paper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01209243
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  • 7
    Electronic Resource
    Electronic Resource
    Dependence of aluminium titanate formation on precursor characteristics (1995)
    Springer
    Journal of materials science 14 (1995), S. 1317-1320 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01262279
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  • 8
    Electronic Resource
    Electronic Resource
    Sintering of thin sheets of alumina prepared by the sol-spray technique (1994)
    Springer
    Journal of materials science 13 (1994), S. 491-493 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00540176
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  • 9
    Electronic Resource
    Electronic Resource
    A cytogenetic description of a new species of the Anopheles culicifacies complex (1988)
    Springer
    Genetica 78 (1988), S. 225-230 
    Details
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Cytogenetic observations on an extensive material of the Anopheles culicifacies complex from the Thenpennai river area, Tamil Nadu, South India show that the populations are made up of four cytologically distinct species. Three of these, labeled A, B and C have already been described. A fourth one, monomorphic for the inversion arrangement + a + b in the X chromosome and i l+hl in the second chromosome, is designated as D, another morphologically indistinguishable sibling species. Each sibling species is characterized by a species-specific type of Y-chromosome. Both of these criteria, inversions and Y-chromosomes can be used to distinguish these important malaria vectors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00055642
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  • 10
    Electronic Resource
    Electronic Resource
    Zone melting-refining in Bi-Pb-Sr-Ca-Cu-O superconductor prepared through the sol-gel method (1994)
    Springer
    Journal of materials science 29 (1994), S. 6453-6457 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A zone melting-refining technique, with a horizontal sample-holding pattern for incorporating grain orientation in sintered bismuth-based superconductor (BPSCCO) is presented. Acrylate precursor-derived BPSCCO powder was uniaxially compacted into strips of 60 mm×10 mm ×2mm and sintered at 845°C for 20 h to obtain 90% density. These strips were zone melted in a three-zone furnace which had an independent temperature control system for each zone. The grain orientation in the sample was studied by scanning electron microscopy and X-ray diffraction. In the case of a BPSCCO-Ag (5%) composite, the silver was seen to flow along the intergrannular boundaries of the BPSCCO grains. The present technique is an easy and fast method to introduce orientation of grains with large aspect ratio into sintered BPSCCO or Ag-BPSCCO composite under partial melting-refining conditions. The possibility of extending the present technique to silver-sheathed wire and tapes is also indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00354003
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