Publication Date:
1991-11-15
Description:
Nitric oxide (NO), a multifaceted bioregulatory agent and an environmental pollutant, can also cause genomic alterations. In vitro, NO deaminated deoxynucleosides, deoxynucleotides, and intact DNA at physiological pH. That similar DNA damage can also occur in vivo was tested by treating Salmonella typhimurium strain TA1535 with three NO-releasing compounds, including nitroglycerin. All proved mutagenic. Observed DNA sequence changes were greater than 99% C----T transitions in the hisG46 (CCC) target codon, consistent with a cytosine-deamination mechanism. Because exposure to endogenously and exogenously produced NO is extensive, this mechanism may contribute to the incidence of deamination-related genetic disease and cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wink, D A -- Kasprzak, K S -- Maragos, C M -- Elespuru, R K -- Misra, M -- Dunams, T M -- Cebula, T A -- Koch, W H -- Andrews, A W -- Allen, J S -- N01-CO-74102/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1991 Nov 15;254(5034):1001-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, MD 21702.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1948068" target="_blank"〉PubMed〈/a〉
Keywords:
Codon
;
*DNA Damage
;
DNA, Bacterial/*chemistry
;
Deamination
;
Mutagenesis
;
Nitric Oxide/*chemistry
;
Salmonella typhimurium
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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